The Bennett Lab


Phenotypic profiling reveals that Candida albicans opaque cells represent a metabolically specialized cell state compared to default white cells.
Ene, I.V., Lohse, M.B., Vladu, A.V., Morschhäuser, J., Johnson, A.D., Bennett, R.J.
MBio. 2016 7(6). PMID: 27879329

A multistate toggle switch defines fungal cell fates and is regulated by synergistic genetic cues. Anderson, M.Z., Porman, A.M., Wang, N., Mancera, E., Huang, D., Cuomo,
C.A., Bennett, R.J.
PLoS Genet. 2016 12(10):e1006353. PMID: 27711197

Fungal Sex: The Ascomycota. Bennett, R.J., Turgeon, B.G. Microbiol Spectr. 2016. 4(5). PMID: 27763253

Systematic genetic screen for transcriptional regulators of the Candida albicans white-opaque switch.
Lohse, M.B., Ene, I.V., Craik, V.B., Hernday, A.D., Mancera, E.,
Morschhäuser, J., Bennett, R.J., Johnson, A.D. Genetics. 2016. 203(4):1679-92.
PMID: 27280690

Phenotypic plasticity regulates Candida albicans interactions and virulence in the vertebrate host.
Mallick, E.M., Bergeron, A.C., Jones, S.K. Jr, Newman, Z.R., Brothers, K.M., Creton, R., Wheeler, R.T., Bennett, R.J.
Front Microbiol. 2016 7:780. PMID: 27303374

Deletion of a Yci1 domain protein of Candida albicans allows homothallic mating in MTL heterozygous cells.
Sun, Y., Gadoury, C., Hirakawa, M.P., Bennett, R.J., Harcus, D., Marcil, A.,
Whiteway, M.
MBio. 2016. 7(2):e00465-16. PMID: 27118591

Budding off: bringing functional genomics to Candida albicans. Anderson, M.Z., Bennett, R.J. (2015)
Brief Funct Genomics. 201615(2):85-94. PMID: 26424829

The parasexual lifestyle of Candida albicans.
Bennett, R.J. (2015)
Curr Opin Microbiol. 201. 28:10-7
PMID: 26210747

Evolutionary selection on barrier activity: Bar1 is an aspartyl protease with novel substrate specificity.
Jones, S.K. Jr, Clarke, S.C., Craik, C.S., Bennett, R.J. MBio. 2015 6(6):e01604-15
PMID: 26604258

Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity.
Scaduto, C.M., Bennett, R.J. (2015) Curr Opin Microbiol.26:102-8.
PMID: 26189047

Candida albicans kinesin Kar3 depends on a Cik1-like regulatory partner protein for its roles in mating, cell morphogenesis, and bipolar spindle formation.
Frazer, C., Joshi, M., Delorme, C., Davis, D., Bennett, R.J., Allingham, J.S. (2015)
Eukaryot Cell. 14(8):755-74. PMID: 26024903

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome.
O'Donoghue, A.J., Knudsen, G.M., Beekman, C., Perry, J.A., Johnson, A.D., DeRisi, J.L., Craik, C.S., Bennett, R.J.
Proc Natl Acad Sci USA. 2015. 12(24):7478-83. PMID: 25944934

Finding a missing gene: EFG1 regulates morpohgenesis in Candida tropicalis.
Mancera, E., Porman, A.M., Cuomo, C.A., Bennett, R.J., Johnson, A.D. (2015)
G3. 5(5):849-56. PMID: 25758825

Genetic and phenotypic intra-species variation in Candida albicans.
Hirakawa, M.P., Martinez, D.A., Sakthikumar, S., Anderson, M.Z., Berlin,
A., Gujja, S, Zeng, Q., Zisson, E., Wang, J.M., Greenberg, J.M., Berman, J., Bennett, R.J.*, Cuomo, C.A.* (2015)
Genome Res. 25(3):413-25. PMID: 25504520

Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.
Bennett, R.J., Forche, A., and Berman, J. (2014) Cold Spring Harb Perspect Med. 31;4(10)
PMID: 25081629.

Convergent evolution of a fused sexual cycle promotes the haploid lifestyle.
Sherwood, R.K., Scaduto, C.M., Torres, S.E., and Bennett, R.J. (2014)
Nature. 2014. 506: 387-390. PMID: 24390351

The cryptic sexual strategies of human fungal pathogens. Ene, I.V., and Bennett, R.J. (2014)
Nature Reviews Microbiology. 2014. 12: 239-251. PMID 24625892

Sexual biofilm formation in Candida tropicalis opaque cells. Jones, S.K.Jr, Hirakawa, M.P., and Bennett, R.J. (2014)
Mol Microbiol. 2014. 92: 383-399. PMID: 24612417

The 'obligate diploid' Candida albicans forms mating-competent haploids.
Hickman MA, Zeng G, Forche A, Hirakawa MP, Abbey D, Harrison BD, Wang YM, Su C, Bennett RJ, Wang Y, Berman J. Nature. 2013. 494:55-9.
PMID: PMC3583542

Candida albicans white and opaque cells undergo distinct programs of filamentous growth. Si H, Hernday AD, Hirakawa MP, Johnson AD, and Bennett RJ.
PLoS Pathogens. 2013. 9: e1003210. PMID: PMC3591317

MTL-independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation.
Porman AM, Hirakawa MP, Jones SK, Wang N, Bennett RJ. PLoS Genetics. 2013. 9: e1003369.
PMID: PMC3605238

Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans.
Lin C-H, Kabrawala S, Fox EP, Nobile CJ, Johnson AD, Bennett
PLoS Pathogens. 2013. 9: e1003305. PMID: PMC3630098

Sensing of the microbial neighborhood by Candida albicans. Mallick EM, Bennett RJ.
PLoS Pathogens. 2013. 9(10): e1003661. PMID: PMC3814570

Human endothelial cells internalize Candida parapsilosis via N- WASP mediated endocytosis.
Shintaku T, Glass K, Hirakawa MP, Longley S, Bennett RJ, Bliss
J, Shaw, S.
Infection and Immunity. 2013. 81: 2777-2787. PMID: PMC3719575

Emerging and emerged pathogenic Candida species: beyond the Candida albicans paradigm.
Papon N, Courdavault V, Clastre M, Bennett RJ. PLoS Pathogens. 2013. 9(9): e1003550.
PMID: PMC3784480

Discovery of a phenotypic switch regulating sexual mating in the opportunistic pathogen Candida tropicalis. Porman AM, Alby K, Hirakawa M, Bennett RJ.
Proc. Natl. Acad. Sci. U. S. A. 2011. 108: 21158-63. PMID: PMC3248515

Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species.
Lin CH, Choi AC, Bennett RJ.
Molecular Biology of the Cell. 2011. 22: 4918-30. PMID: PMC3237633

Inter-species pheromone signaling promotes biofilm formation and same-sex mating in Candida albicans.
Alby K, Bennett RJ.
Proc. Natl. Acad. Sci. U. S. A. 2011. 108: 2510-5. PMID: PMC3038756

Identification of a cell death pathway in Candida albicans during the response to mating pheromones. Alby K, Schaefer D, Sherwood RK, Bennett RJ.
Eukaryotic Cell. 2010. 9: 1690-1701.
PMID: PMC2976293

Analogous telesensing pathways regulate mating and virulence in two opportunistic human pathogens.
Bennett RJ, Dunny GM. mBio. 2010. 1: e00181-10.
PMID: PMC2934609

Coming of age – sexual reproduction in Candida species. Bennett RJ.
PLoS Pathogens. 2010. 6: e1001155. PMID: PMC3009590

Sexual reproduction in the Candida clade: cryptic cycles, diverse mechanisms, and alternative functions.
Alby K, Bennett RJ.
Cell. Mol. Life Sciences. 2010. 67: 3275-3285. PMID: PMC2935507

Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans.
Ene I, Bennett RJ.
Eukaryotic Cell. 2009. 8: 245-249.
PMID: PMC2794213

A Candida-based view of fungal sex and pathogenesis.
Bennett RJ.
Genome Biology. 2009. 10:230. PMID: PMC2728522

Homothallic and Heterothallic mating in the opportunistic pathogen Candida albicans.
Alby K, Schaefer D, Bennett RJ. Nature. 2009. 460:890-893.
PMID: PMC2866515

To Switch or Not to Switch? Alby K, Bennett RJ.
Communicative and Integrative Biology. 2009. 2:6, 1-3. PMID: PMC2829826

Fungal meiosis and parasexual reproduction - lessons from pathogenic yeast. Sherwood R, Bennett RJ.
Current Opinion in Microbiology. 2009. 12: 599-607. PMID: PMC2846606

Stress-induced phenotypic switching in Candida albicans. Alby K, Bennett RJ.
Mol. Biol. Cell. 2009. 20: 3178-91. PMID: PMC2710840

The microtubule motor protein Kar3 is required for normal mitotic division and morphogenesis in Candida albicans. Sherwood RK, Bennett RJ.
Eukaryotic Cell. 2008. 7: 1460-1474.
PMID: PMC2547067

The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains.
Forche A, Schaefer D, Alby K, Johnson AD, Berman J, Bennett
PLoS Biology. 2008. 6: e110. PMID: PMC2365976

Barrier activity in Candida albicans mediates pheromone degradation and promotes mating.
Schaefer D, Cote P, Whiteway M, Bennett RJ. Eukaryotic Cell. 2007. 6: 907-918.
PMID: PMC1951518

The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans.
Bennett RJ, Johnson AD.
Mol. Microbiol. 2006. 62: 100-119. PMID: 16987174

Mating in Candida albicans and the search for a sexual cycle. Bennett RJ, Johnson AD.
Annu Rev Microbiol. 2005. PMID: 15910278

Nuclear fusion occurs during mating in Candida albicans and is dependent on the KAR3 gene.
Bennett RJ, Miller MG, Chua PR, Maxon ME, Johnson AD. Mol Microbiol. 2005. 55(4):1046-59.
PMID: 15686553

Identification and characterization of a Candida albicans mating pheromone. Bennett RJ, Uhl MA, Miller MG, Johnson AD.
Mol Cell Biol. 2003. 23(22):8189-201. PMID: PMC262406