My research interest has been focusing on the effects of protein modifications on cell functions. Recently we have found that acetylation of IFNaR2 regulates the antiviral signal transduction of interferon alpha and phosphorylation of RNAse III enzyme Drosha localizes this protein in the nucleus. We are investigating the influences of Drosha modifications on microRNA biogenesis and its implications in the tumorigenesis and therapy of human cancers.