Ongoing research focuses on dissecting the molecular mechanisms of G protein-coupled estrogen receptor biogenesis, surface expression, desensitization and trafficking, and its pathological roles in diseases such as breast cancer.

Awards

1992, 1993 Excellent Teacher Award, Sun Yat-sen University of Medical Sciences (SUMS), China
1994 Research Project Achievement Award, SUMS, China
1995 Scientific Progress Award, Ministry of Health, China
1999, 2000 Travel Awards, Kagoshima Prefecture International Communication Society, Japan
1999-2000 Scholarship, Ministry of Education, Science and Culture of Japan, Japan
2000 Travel Award, Kato Memorial Bioscience Foundation, Japan
2000-2001 Fellowship, Japan-China Medical Association, Japan
2000, 2002 Publication Award, the Kodama Foundation for Research of Medical Science, Japan
2000-2002 Teaching Assistantship, Faculty of Medicine, Kagoshima University, Japan
2001-2003 Fellowship, Japan Society for the Promotion of Science, Japan
2001-2003 Research Award, Japan Society for the Promotion of Science (No. 200100115-14), Japan
2005 Travel Award, Neuroscience Center of Excellence, LSUHSC, USA
2005 Travel Award, Society of Neuroscience, USA
2006 Excellent Presentation Award, Neuroscience Center of Excellence, LSUHSC, USA
2007 Travel Award, International Herpes Simplex Virus Workshop, North Carolina, USA
2012-pres Member of Editors & Editorial Board, Journal of Tropical Diseases
2012-pres Member of Editors & Editorial Board, Journal of Tropical Medicine & Surgery

Funded Research

Funded
•COBRE for Perinatal Biology (5P20RR018728-10), National Institute of General Medical Sciences (8 P20 GM103537-10; PI: James Padbury)
Project I: in vivo and in vitro Model of Pre-eclampsia Pathology
Role: PI

Completed
•Grant-in-Aid for Scientific Research, (Basic Research (C)) (No. 13833006), 2001-2003
Effect of Dioxin prenatal exposure on the behavior of mouse
The Japanese Ministry of Education, Sports, Science and Technology
Role: Co-investigator (PI: S. Kuchiiwa)

•Research Grant (No. 200100115-14), 2001-2003
Neurotoxic effect of Dioxin
Japan Society for the Promotion of Science, JAPAN
Role: PI

Selected Publications

• 1. Cheng, S.B. and Filardo, E.D. (2012) The Trans-Gogi network (TGN) as a regulatory node for beta1-adrenergic receptor down-modulation and recycling, J Biol Chem (in press) doi:10.1074/jbc.M111.323782(2012)
• 4. Cheng, S. B., Graeber C.T., Quinn J., and Filardo E.D. (2011) Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus. Steroids 76(9):892-6.(2011)
• 3. Cheng, S. B., Ferland, P., and Bearer, E.L. (2011) Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS ONE 6(3): e17966.doi: 10.1371/journal.pone.0017966.(2011)
• 2. Cheng, S. B., Quinn J., Graeber C.T., and Filardo E.D. (2011) Downmodulation of GPER/GPR30 from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem 286(25): 22441-55.(2011)
• 5. Cheng, S. B., Stephanie, A. Amici, Ren, X.Q., Susan, B. McKay, Treuil, M.W., Lindstrom J. M, Rao, J., and Anand, R. (2009) Presynaptic targeting of alpha4beta2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J Biol Chem 284 (35): 23251-9.(2009)
• 6. Ren, X. Q., Cheng, S. B., Treuil, M. W., Mukherjee, J., Rao, J., Lindstrom, J. M., and Anand, R. (2005) Structural determinants of a4b2 nicotinic acetylcholine receptor trafficking. J Neurosci, 25: 6676-86.(2005)
• 9. Cheng, S.B., Kuchiiwa, S., Gao, H., Kuchiiwa, T., Nakagawa, S. (2003) Morphological study of orexin neurons in the hypothalamus of the Long-Evans rat, with special reference to co-expression of orexin and NADPH-diaphorase or nitric oxide synthase activities. Neurosci. Res. 46: 53-62.(2003)
• 8. Cheng, S.B., Kuchiiwa, S., Gao, H., Kuchiiwa, T., Nakagawa, S. (2003) Dioxin exposure down-regulates nitric oxide synthase and NADPH-d activities in the hypothalamus. Neurosci Lett. 345: 5-8.(2003)
• 7. Cheng, S.B., Kuchiiwa, S., Kawachi, A., Gao, H.Z., Gohshi, A., Kozako, T., Kuchiiwa, T., Nakagawa, S. (2003) Up-regulation of methionine-like enkephalin immunoreactivity by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment in the forebrain of the Long-Evans rat. J Chem Neuroanat, 25: 73-82.(2003)
• 13. Kozako, T., Kawachi, A., Cheng, S.B., Kuchiiwa, S., Motoya, T., Nakagawa, S., Yamada, K. (2002) Role of the vestibular nuclei in endothelin-1-induced barrel rotation in rats. Eur. J. Pharmacol. 454: 199-207.(2002)
• 12. Kuchiiwa, S., Cheng, S.B., Nagatomo, I., Akasaki, Y., Uchida, M., Tominaga, M., Hashiguchi, W., Kuchiiwa, T. (2002) In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin decreases serotonin-immunoreactivity in the raphe nuclei of mice. Neurosci Lett 317 (2): 73-76.(2002)
• 10. Cheng, S.B., Kuchiiwa, S., Nagatomo, I., Akasaki, Y., Uchida, M., Tominaga, M., Hashiguchi, W., Kuchiiwa ,T., Nakagawa, S. (2002) 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin pretreatment induces c-Fos expression in the forebrain of the Long-Evans rat, Brain Res 931 (2): 176-180.(2002)
• 11. Cheng, S.B., Kuchiiwa, S., Kuchiiwa, T., Nakagawa, S. Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment on methionine-enkephalin immunoreactivity in the brain of the Long-Evans rat. Organohalogen Compounds 2002, Volume 57, p407-409.(2002)
• 14. Cheng, S.B., Kuchiiwa, S., Kuchiiwa, T., Nonaka, S., Nakagawa, S. (2001) Presence of nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal gland of the cat: an immunofluorescent and retrograde tracer double-labeling study. J Chem Neuroanat 22(3): 147-155.(2001)
• 16. Kuchiiwa, S., Cheng , S.B., Kuchiiwa, T. (2000) Morphological distinction between the vasomotor neurons and the secretomotor neurons innervating the cat cranio-oro-facial regions. Neurosci Lett 288(3): 219-222.(2000)
• 15. Cheng, S.B., Kuchiiwa, S., Kuchiiwa, T., Nakagawa, S. (2000) Three novel neuronal pathways to the lacrimal gland of the cat: an investigation with cholera toxin B subunit as a retrograde tracer. Brain Res 873(1): 160-164.(2000)
• 17. Cheng, S.B.(corresponding author), Hayakawa, T., Kuchiiwa, S., Maeda, S., Ito, H., Seki M., Nakagawa, S. (1999) Evidence for the collateral innervation of the esophagus and the heart from neurons in the compact formation of the ambiguus nucleus of the rat. Brain Res 832:171-174.(1999)