Oxidative stress may interfere with the stability & activity of a microbial pathogen's protein and lipid complexes critical for their membrane integrity, respiration, protein & nucleic acid synthesis, & ability to invade and multiply in our tissues. My interests lie in increasing our understanding of the details of oxidative stress and its mitigation by successful pathogens so we can better protect ourselves against infectious agents transmitted through water, air supplies & contact exposure.

Institutions

Bu

Research Description

OXIDATIVE STRESS AND INFECTIOUS DISEASE

Oxidative stress may interfere with the stability and activity of a microbial pathogen's protein and lipid complexes critical for their membrane integrity, respiration, protein and nucleic acid synthesis, and ability to invade and multiply in our tissues. Two settings are of special interest in considering oxidative stress for control of a pathogen's virulence. One of these is in phagolysosomes in which pathogens may be subjected to an oxidative burst as part of the defensive properties of our phagocytes. A second setting is in the oxidative disinfection of our water supplies through halogens, aeration and ozone and other active forms of oxygen. Some microbes are able to evade different stages of these processes, resist inactivation and remain virulent. My interests lie in increasing our understanding of the details of oxidative stress and its mitigation by successful pathogens so that we can better protect ourselves against infectious agents transmitted through water and air supplies and contact exposure.

Awards

Phi Beta Kappa, 1951-present
Sigma Xi, 1954-present
National Science Foundation Predoctoral Fellow, 1954-1955
American Cancer Society Postdoctoral Fellow, 1955-1957
U.S. Public Health Service Senior Fellow, 1965-1966

Affiliations

- Society of the Sigma Xi
- American Association for the Advancement of Science
- American Society for Microbiology
- Genetics Society of America
- American Society for Human Genetics

Funded Research

N/A

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