Dr. Gareen focuses on cancer screening trials. She is interested in the downstream consequences of screening, including medical care utilization, iatrogenic consequences, changes in quality of life, and the impact of screening and screening results on smoking cessation.

Dr. Gareen also focuses on potential biases arising in cancer screening trials.

Biography

Dr. Gareen has a Ph.D. in Epidemiology from U.C.L.A. School of Public Health. She is interested in using epidemiologic methods to evaluate new medical technologies. She currently is working on evaluating lung cancer screening in the National Lung Cancer Screening Trial (NLST). In this trial she is responsible the abstraction of medical records to evaluate the downstream consequences of screening, changes in quality of life associated with screening and screening result, smoking, and assignment of cause of death.

Dr. Gareen co-teaches clinical trials in the Department of Community Health. In the past, she taught Health and Human reproduction. Her dissertation work focused on reproductive epidemiology.

Institutions

Bu

Research Description

Dr. Gareen has been involved with the American College of Radiology Imaging Network (ACRIN) since its inception. As part of ACRIN, she has worked on the National Lung Cancer Screening Trial, the National Colonography Screening Trial, and the National Oncologic PET Registry.

Awards

Pew Health Policy Fellow 1989-1992

Affiliations

Society for Epidemiologic Research

Funded Research

U01 CA79778 (Gatsonis) 03/02/1999-12/31/2007
NCI
Biostatistics Data Management Center for ACRIN
The American College of Radiology Imaging Network (ACRIN) is a national cooperative group, organized and funded by the National Cancer Institute in 1999 to conduct multi-center, interdisciplinary clinical evaluations of diagnostic imaging in the early detection and diagnosis, staging, and treatment of cancer. ACRIN's ultimate goal is to develop and disseminate scientific knowledge that will help reduce cancer-related mortality and morbidity and improve the quality of life of cancer patients. The Biostatistics and Data Management Center of ACRIN is directed by Constantine Gatsonis and is operated jointly by the Center for Statistical Sciences, Brown University and the American College of Radiology. The main responsibility for data collection and management is with the Philadelphia office of the ACR. The overall direction of the BDMC and the main responsibility for study design, monitoring, and data analysis is with Brown. In addition to his role as Network Statistician of ACRIN, Dr. Gatsonis is the protocol statistician in current ACRIN studies of screening for breast and lung cancer and in a study of diagnostic imaging for cervical cancer.

U01 CA79778 S2 (Gatsonis) 07/01/2002-12/31/2007
NCI
Biostatistics Data Management Center for NLST
This proposal responds to the need for biostatistical support and methodologic leadership in the development and implementation of contemporary screening for the detection of lung cancer.

U01 CA79778 S2 (Gatsonis) 01/01/2005-12/31/2007
NCI
Biostatistics Data Management Center for Computerized Tomographic Colonography Trial
This proposal responds to the need for biostatistical support and methodological leadership to ACRIN investigators in the development and implementation of Protocol 6664.

Courses Taught

• Clinical Trials Methodology (BC00234)

Selected Publications

• Lazarus E, Mainiero MB, Gareen IF. Effect of referring physician specialty and practice type on referral for image-guided breast biopsy. Journal of the American College of Radiology, 2005;2:488-493.(2005)
• Church T. and NLST Executive Committee Chest radiography as the comparison for spiral CT in the National Lung Screening Trial. Academic Radiology, 2003;10:713-715.(2003)
• Gareen I, Morgenstern H, and Greenland S. Explaining the association of maternal age with cesarean delivery for nulliparous and parous women, J Clin Epidemiol. 2003; 56: 1100-10.(2003)
• Gareen I, Gatsonis C. A primer on multiple regression models for diagnostic imaging research, Academic Radiology, 2003;229:305-10.(2003)
• Gareen IF. Intrauterine devices and pelvic inflammatory disease. Curr Womens Health Rep. 2003;3:280-7.(2003)
• Mayo-Smith WW, Rhea JT, Smith WJ, Cobb CM, Gareen IF, Dorfman GS. Transportable versus fixed platform CT scanners: comparison of costs. Radiology. 2003;226:63-8.(2003)
• Mainiero MB, Gareen IF, Bird CE, Smith W, Cobb C, Schepps B. Preferential use of sonographically guided biopsy to minimize patient discomfort and procedure time in a percutaneous image-guided breast biopsy program. J Ultrasound Med 2002;21:1221-1226.(2002)
• Lonks JR, Garau J, Gomez L, Xercavins M, Ochoa De Echaguen A, Gareen IF,Reiss PT, Medeiros AA. Failure of Macrolide Antibiotic Treatment in Patients with Bacteremia Due to Erythromycin-Resistant Streptococcus pneumoniae. Clin Infect Dis. 2002;35:556-64.(2002)
• Gareen I, Greenland S, and Morgenstern H. Intrauterine Devices and Pelvic Inflammatory Disease: Meta-analyses of Published Studies, 1974-1990 Epidemiology 2000;11:589-597.(2000)
• Dicostanzo D, Rosen PP, Gareen I, and Lesser M. Prognosis in infiltrating lobular carcinoma: an analysis of "classical" and variant tumors. Am J Surg Pathol 1990;14:12-23.(1990)
• Wojtasek DA, Texidor HS, Govini AF, and Gareen IF. Diagnostic quality of mammograms obtained with a new low-radiation-dose dual-screen and dual-emulsion film combination. AJR 1990;154:265-270.(1990)
• Staiano-Coico L, Wong R, Jacobsen I, Morrissey KP, Lesser ML,Gareen IF, McMahon C, Cennerazzo W, Decosse J. DNA content of rectal scrapings from individuals with familial adenomatous polyposis syndrome: an interim report. Cancer 1989;64:2579-2584.(1989)