Maureen Chung's current research is focused on the function of MUC1 a tumor associated antigen that is abnormally expressed in breast cancer. Her research has been supported by the American Cancer Society. Additonally, she has published extensively on the contemporary management of breast cancer and the impact of breast cancer screening on presentation and treatment in Rhode Island.

Biography

Maureen A. Chung, MD, PhD is a surgical oncologist at Rhode Island Hospital and an Associate Professor of Surgery at Brown University, Providence, RI. Her work focuses on the function of MUC1, a tumor associated antigen that is abnormally expressed in breast cancer. Her research has been supported by the American Cancer Society.

Dr. Chung is a graduate of McGill University in Montreal, Canada, where she earned her medical degree and a master's degree in science (experimental surgery). In addition, Dr. Chung earned a PhD in pathobiology from Brown University. Dr. Chung completed a residency in general surgery at McGill University and a surgical oncology fellowship at Brown Medical School. A member of the Board of Directors of the Rhode Island Breast Cancer Coalition, Dr. Chung is also an associate editor of the American Journal of Clinical Oncology, an external grant reviewer for the Arkansas Breast Cancer Research Program and a contributing editor for Women's Oncology Review. She is a member of the American Association of Cancer Research, American Society of Breast Surgeons, the American College of Surgeons, the New England Cancer Society, the Rhode Island Medical Women's Association, the Association of Academic Surgeons, the Society of University Surgeons, and the Society of Surgical Oncology.

Institutions

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Research Description

Maureen A. Chung, MD, PhD, is a surgical oncologist at Rhode Island Hospital and an Associate Professor of Surgery at Brown University, Providence, R.I. As a clinician, she has published extensively on the contemporary management of breast cancer and the impact of mammographic screening on breast cancer presentation, treatment and outcome in Rhode Island. Her basic science interests are focused on the role of MUC1, a tumor associated antigen that is abnormally expressed in breast cancer. Her laboratory is interested in MUC1 cellular localization and its role in chemosensitivity.

Dr. Chung is a graduate of McGill University in Montreal, Canada, where she earned her medical degree and a master's degree in science (experimental surgery). In addition, Dr. Chung earned a PhD in pathobiology from Brown University. Dr. Chung completed a residency in general surgery at McGill University and a surgical oncology fellowship at Brown Medical School. A member of the Board of Directors of the Rhode Island Breast Cancer Coalition, Dr. Chung is also an associate editor of the American Journal of Clinical Oncology, an external grant reviewer for the Arkansas Breast Cancer Research Program, and a contributing editor for Women's Oncology Review. She is a member of the American Association of Cancer Research, American Society of Breast Surgeons, the American College of Surgeons, the New England Cancer Society, the Rhode Island Medical Women's Association, the Association of Academic Surgeons, the Society of University Surgeons, and the Society of Surgical Oncology.

Awards

July 1995 Sandoz Clinical Research Fellow
Royal College of Physicians and Surgeons of Canada

July 1996 Bayer Research Fellow
Association for Academic Surgery

July 2000 Outstanding Young Researcher Award
Expedition Inspiration

July 2001 Dean's Teaching Excellence Award
Brown Medical School

June 2002 Excellence-in-Teaching Award
Brown Women and Infants' Hospital

July 2002 Dean's Teaching Excellence Award
Brown Medical School

November 2002 Inspiration in Research Award
Rhode Island Breast Cancer Coalition

Affiliations

1998- Present Women's Cancer Screening Program

July 2000 - Present Board of Directors, RI Breast Cancer Coalition

September 2001- Present External grant reviewer
Arkansas Breast Cancer Research Program

October 2001 - Present Contributing Editor
Women's Oncology Review

January 2002 External Evaluator for academic appointments and tenure candidacy, McGill University

July 2002 – Present Women and Infants representative on the council of the Rhode Island Chapter of American College of Surgeons

July 2003 – December 2006 Associate Editor
American Journal of Clinical Oncology

July 2003 – Present Ad hoc reviewer
Annals of Surgical Oncology

June 2004 – Present Editorial Board Member
Current Cancer Therapy Reviews

2004-Present Guest Reviewer
Canadian Medical Association Journal

2004-Present AWS Grants/Awards Committee Member
Association of Women Surgeons

2006-Present Editorial Review Board
Bentham Science Journal

Funded Research

CRTG-02-237-01-CCE Chung (PI) July 2002-June 2006
The American Cancer Society Clinical Research Training Grant. Interaction of a MUC1 Protein with E-cadherin and B-catenin in Breast Cancer ($440,000)

November 2002 Inspiration in Research Award
Rhode Island Breast Cancer Coalition
Development of a BCG-based MUC1 vaccine for breast cancer. ($25,000)

Completed Grants:
Subproject (Chung PI) October 2002 - September 2005
National Institutes of Health Centers of Biomedical Research Excellence (NIH COBRE) Center for Cancer Research Development (Hixson, PI)
Development and preclinical evaluation of BCG-based MUCI and CD155 vaccines for hepatocellular immunotherapy ($170,000/yr)

(Chung, PI) March 2004-March 2005
National Institutes of Health COBRE Center for Cancer Research Development – Translational Award
Preclinical evaluation of BCG-hIL2 MUC1 in human transgenic mice that spontaneously develop pancreatic cancer ($25,000)
(Chung, PI)
RO1-MUC1 Cleavage by Gamma Secretase Drives Tumor Growth in Breast Cancer
(To be re-submitted March 2009)

Teaching Experience

July 2001 Dean's Teaching Excellence Award
Brown Medical School

June 2002 Excellence-in-Teaching Award
Brown Women and Infants' Hospital

July 2002 Dean's Teaching Excellence Award
Brown Medical School

Selected Publications

• Cady B, Chung MA, Michealson JS. A decline in breast cancer incidence. N Eng J Med 2007;357:511(2007)
• Cady B. Chung MA. Pilot trial of computerized decision aid for breast cancer prevention. Breast J 2007;13:539-40.(2007)
• Yuan Z, Wong S, Borrelli A, Chung MA. Down-regulation of MUC1 in cancer cells inhibits cell migration by promoting E-cadherin/catenin complex formation. Biochem Biophys 2007; 362/3:740-6.(2007)
• Chung MA, Cady B. (Letter to Editor) Genetic Counseling and Management of Newly Diagnosed Breast Cancer Patients at Genetic Risk for BRCA Germline Mutations. Breast J 2006; 12:282-3.(2006)
• Tsikitis V, Chung MA. The Biology of DCIS. Am J Clin Onc 2006; 3: 305-10(2006)
• Coburn N, Clarke-Pearson E, Cady B, Fulton J, Chung MA. A Novel Approach to T Classification in TNM Staging of Breast Cancer. Am J Surg 2006; 192: 434-8.(2006)
• Cady B, Chung MA. Surgical Treatment Planning in Newly Diagnosed Breast Cancer Patients at High Risk for BRCA-1 or BRCA-2 Mutation. Response Letter Breast J 2006; 10: 473-4.(2006)
• Cady B, Chung MA. (Editorial) Mammographic Screening: No Longer Controversial. Amer J of Clin Oncol 2005; 28: 1-4.(2005)
• Cady B, Chung MA. The prevention of invasive breast carcinoma. Cancer 2004; 101: 2147-2151.(2004)
• Moore R, Chung MA, Granai CO, Gajewski W, Steinhoff MM. Incidence of metastasis to the ovaries from nongenital tract primary tumors. Gynecol Oncol 2004 Apr; 93: 87-91.(2004)
• Lee SH, Chung MA, Chelmow D, Cady B. Avoidance of adjuvant radiotherapy in selected patients with invasive breast cancer. Ann Surg Oncol 2004; 11: 316-21.(2004)
• Tsikitis V, Chung MA, Cady B. Scientific Basis of Neoadjuvant Therapy. Seminars in Breast Disease 2004; 7: 51-57.(2004)
• Spencer D, Potter J, Chung MA, Fulton J, Hebert W, Cady B. Mammographic screening and disease presentation of breast cancer patients who die of disease. Breast J 2004; 10: 298-303(2004)
• Coburn NG, Chung, MA, Fulton J, Cady B. Decreased Breast Cancer Size, Stage and Mortality in Rhode Island: An Example of a Well-Screened Population. Cancer Control 2004; 11: 222-30(2004)
• Cady B, Chung MA. The prevention of invasive breast carcinoma. Cancer 2004; 101: 2147-51.(2004)
• Tsikitis V, Chung MA, Cady B. Scientific Basis of Neoadjuvant Therapy. Seminars in Breast Disease 2004; 7: 51-7.(2004)
• Lee SH, Akuete K, Fulton J, Chelmow D, Chung MA, Cady B. An increased risk of breast cancer after delayed first parity. Am J Surg 2003; 186:409-412.(2003)
• Mainiero MB, Koelliker SL, Zeinowicz R, Chung MA, Schepps B. Mammography of autologous musculocutaneous flaps. J Women's Imaging 2003; 5: 20-24.(2003)
• Zunzunegui RG, Chung MA, Oruwari J, Golding D, Marchant DJ, Cady B. Casting type mammographic calcifications with high grade DCIS and invasion: a more aggressive disease? Arch Surg 2003; 138:537-45.(2003)
• Chung MA, Luo Y, O'Donnell M, Rodriguez C, Hebert W, Sharma S, Chang H. Development and pre clinical evaluation of a BCG-MUC1 based novel breast cancer vaccine. Cancer Res 2003; 63:1280-7.(2003)
• Lee SH, Chung MA, Quddus M, Steinhoff M, Cady B. The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression and hormone receptor status in breast cancer. Am J Surg 2003; 186:348-350(2003)
• Chung MA, DiPetrillo T, Hernandez S, Masko G, Wazer D, Cady B. Treatment of the axilla by tangential breast radiotherapy in women with invasive breast cancer. Am J Surg 2002; 184:401-2.(2002)
• Oruwari J, Chung MA, Koelliker S, Steinhoff M, Cady B. Axillary staging using ultrasound-guided and fine needle aspiration biopsy in locally advanced breast cancer. Am J Surg 2002; 184:307-9.(2002)
• Chung MA, Steinhoff M, Cady B. Clinical axillary recurrence in breast cancer patients after a negative sentinel node biopsy. Am J Surg 2002; 184:310-4.(2002)
• Wazer DE, Berle L, Graham R, Chung M, Rothschild J, Graves T, Cady B, Ulin K, Ruthazer R, DiPetrillo TA. Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer; HDR brachytherapy for early breast cancer. Int J Radiat Oncol Biol Phys 2002; 53:889-97.(2002)
• Neuschatz AC, DiPetrillo T, Steinhoff M, Safaii H, Yunes M, Landa M, Chung M, Cady B, Wazer D. The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast: Margin width and residual tumor in DCIS. Cancer 2002; 19:1917-24.(2002)