Successful wound healing requires the coordinated activities of the multiple cell types that constitute the inflammatory and reparative response to tissue injury. The definition of the growth factors, cytokines, matrix components, and other products present in the wound that modulate wound healing-cell functions will allow a better understanding of the process of repair and promises clinical applications that will allow active therapeutic intervention. The development of these applications will require a better characterization of the phenotype and biology of inflammatory cells, most specifically as it relates to modulation by the wound environment.

Biography

Dr. Jorge E. Albina is a Professor of Surgery and Director of Surgical Research at Rhode Island Hospital/Alpert Medical School of Brown University, and Director of Nutritional Support Services, Department of Surgery, Rhode Island Hospital. 



As Alpert Medical School faculty, Dr. Albina instructs the Surgical Nutrition Rotation, Surgical Residency Program, Nutrition Surgical Core Clerkship Course, Basic Science in Surgery, and the Integrated Program in Surgery. 



A faculty member of the Graduate Program in Pathobiology, Dr. Albina is actively engaged in teaching undergraduates, graduates and Alpert Medical School students and serves as Doctoral Thesis Advisor and Doctoral Thesis Committee Member.

Dr. Albina is also a Faculty Sponsor for Brown University's Summer Research Early Identification Program, which is funded by the NIH Short Term Training for Minority Students grant and The Leadership Alliance. He is also the Principal Investigator on a T32 Trauma & Inflammation Research Training grant.

As Director of Surgical Research, Dr. Albina is NIH funded and has authored over 70 peer-reviewed manuscripts. His research area of expertise is wound healing and inflammation, with emphasis on clinical applications that will allow active therapeutic intervention.

Dr. Albina is a frequently requested reviewer for many peer-reviewed journals and a member of the NIH SAT Study Section. He is a renowned speaker, with over 200 invited presentations worldwide.

Institutions

RIH

Research Description

The Surgical Metabolism laboratory is focused on the definition of the phenotypes of wound cells, and of the wound environment as a determinant of these phenotypes. Particular emphasis has been placed on the characterization of the wound macrophage phenotype and of the cellular and extracellular signals encountered by monocytes arriving at a site of injury that modulate their differentiation into wound healing macrophages.

Awards

POSTGRADUATE HONORS AND AWARDS:

AWARDS:

2007-2008 Outstanding Teaching Faculty Award
The Warren Alpert Medical School of Brown University
Department of Surgery
Providence, RI

2001 Dean's Teaching Excellence Award
Bio 282: Pathophysiology-Nutrition
Medicine and Biological Sciences
Brown Medical School
Providence, RI

2000 Rhode Island Dietetic Association
24 Carrot Award
Awarded for being "an outstanding advocate of the dietetics profession, publicly promoting optimal nutrition, health and well being".
Providence, RI

1993-1994 Faculty Teaching Award
Program in Surgery
Brown Medical School
Providence, RI

1991 Masters Degree ad eundem
Brown University
Providence, RI

1973 Mar del Plata Society of Surgeons Award
Mar del Plata, Argentina

1972 Province of Buenos Aires Award
Scholar award
Province of Buenos Aires, Argentina

1972 A.C. Freindenberger Award
University of La Plata, Argentina

Affiliations

American Association for the Advancement of Science
American Association of Molecular and Cellular Biology
American Cancer Society
American Institute of Nutrition
American Medical Association
American Society for Cell Biology
American Society for Clinical Nutrition
American Society for Parenteral & Enteral Nutrition
Association for Academic Surgery
Hellenic Society of Parenteral and Enteral Nutrition, Honorary Member
Rhode Island Medical Society
Shock Society
Society for Leukocyte Biology
Society for Parenteral Alimentation
Surgery Biology Club III, American College of Surgeons
Wound Healing Society

Funded Research

GRANTS:

1. 1989-2010
Cellular Molecular Biology of Inflammation and Repair.
NIH
R01GM 42859-19 Principal Investigator Total Costs: $1,324,400

2. 2006-2011
Neutrophil-macrophage Interactions Govern Liver Immunity.
NIH/NIDDKD
RO1 DK068097-03 Collaborator Total Costs: $900,000

3. 2009-2013
Differential Effects of Sepsis on Immune Cell Function
NIH/NIGMS
2 R01 GM046354-15A2 Collaborator Total Costs: $1,000,000

4. 2004-2014
Trauma and Inflammation Research Training.
NIH
1 T32 GM065085-05 Principal Investigator Total Costs: $1,158,247

5. 2007-2011
Hetrogeneity of Wound Macrophages.
NIH/NIGMS
1 K08 GM079227-02 Mentor Total Costs: $607,365

6. 2004-2009
Programmed Cell Death: Role in Septic Immune Dysfunction.
NIH/NIGMS
RO1 GM053209-15 Collaborator Total Costs: $1,114,841

7. 2002-2012
Effect of Neutrophil Priming on Chemotaxis and Signaling.
NIH/NIGMS
R01 GM66194-05A2 Collaborator Total Costs: $1,219,208

8. 2002-2009
COBRE Center for Cancer Research Development
NIH/National Center for Research Resources
5P20RR017695-05 Collaborator Total Costs: $5,793,728

Teaching Experience

As Alpert Medical School faculty, Dr. Albina instructs the Surgical Nutrition Rotation, Surgical Residency Program, Nutrition Surgical Core Clerkship Course, Basic Science in Surgery, and the Integrated Program in Surgery. 



A faculty member of the Graduate Program in Pathobiology, Dr. Albina is actively engaged in teaching undergraduates, graduates and Alpert Medical School students and serves as Doctoral Thesis Advisor and Doctoral Thesis Committee Member.

Dr. Albina is also a Faculty Sponsor for Brown University's Summer Research Early Identification Program, which is funded by the NIH Short Term Training for Minority Students grant and The Leadership Alliance. He is also the Principal Investigator on a T32 Trauma & Inflammation Research Training grant.

Selected Publications

• Thomay, A.A., Daley, J.M., Sabo, E., Worth, P.J., Shelton, L.J., Reichner, J.S., Albina, J.E. Disruption of interleukin-1 (IL-1) signaling improves the quality of wound healing. American Journal of Pathology 174:2129-2136, 2009.(2009)
• Daley, J.M., Thomay, A.A., Reichner, J.S., and Albina, J.E. The phenotype of wound macrophages. Journal of Immunology, in press, 2009.(2009)
• Xu, J., Reichner, J.S., Mastrofrancesco, B., Henry Jr., W., Albina, J.E. Prostaglandin E2 inhibits lipopolysaccharide-induced type I IFN (IFNβ) production in murine J774A.1 macrophages. Journal of Immunology 180:2125-2131, 2008(2008)
• Daley, J.M., Thomay, A., Connolly, M., Reichner, J. and Albina, J.E. Use of Ly6Gspecific monoclonal antibody to deplete neutrophils in mice. Journal of Leukocyte Biology 83:64-70, 2008.(2008)
• Lavigne, L.M., O'Brien, X.M., Kim, M., Janowski, J. W., Albina, J.E., Reichner, J.S. Integren engagement mediates the human PMN leukocyte response to a fungal pathogen-associated molecular pattern. Journal of Immunology 178:7276-7282, 2007(2007)
• Lavigne, L., Albina, J.E., and Reichner, J.S. The effects of beta-glucan on adhesion-dependent human neutrophil functions. Journal of Immunology 177(12): 8667-75, 2006.(2006)
• LeBlanc, B.W., Albina, J.E. and Reichner, J.S. The effect of PGG-β-glucan on neutrophil chemotaxis in vivo. Journal of Leukocyte Biology 79: 667-675, 2006.(2006)
• Chung, A.S., Guan, Y-J., Yuan, Z-L., Albina, J.E., and Chin, Y.E. Ankyrin repeat and SOCS Box3 (ASB3) mediates ubiquitination and degradation of TNF Receptor-II. Molecular and Cellular Biology 25: 4716-4726, 2005.(2005)
• Daley, J.M., Ivanenko-Johnston, T., Reichner, J.S., and Albina, J.E. Transcriptional regulation of TNF-α production in neutropenia. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 288:R409-R412, 2005(2005)
• Din, Y., Chung, C.-S., Newton, S., Chen, Y., Carlton, S., Albina, J.E., and Ayala, A. Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock, 22:137-144, 2005.(2005)
• Daley, J.M., Reichner, J.S., Mahoney, E.J., Manfield, L., Henry, W.L., Jr., Mastrofrancesco, B., and Albina, J.E. Modulation of macrophage phenotype by soluble product(s) released from neutrophils. Journal of Immunology 174:2265, 2005.(2005)
• Albina, J.E., Mahoney, E.J., Daley, J.M., Wesche, D.E., Morris, S.M., Jr. and Reichner, J.S. Macrophage arginase regulation by C/EBP/β. Shock 23:168-172, 2005.(2005)
• Tsikitis, V.L., Albina, J.E., and Reichner, J.S. β-glucan affects leukocyte navigation in complex chemotactic gradients. Surgery, 136:384-389, 2004.(2004)
• Tsikitis, V.L., Morin, N.A., Harrington, E.O., Albina, J.E., and Reichner, J.S. β-glucan protects endothelial barrier function from activated neutrophils. Journal of Immunology, 173:1284-1291, 2004.(2004)
• Reichner, J.S. and Albina, J.E. Determination of the role of hypoxia-inducible factor 1 in wound healing. Methods in Enzymology,381:527-538, 2004.(2004)