The orthopaedic oncology laboratory is devoted to elucidating the molecular genetic underpinnings of orthopaedic tumors. A long-term commitment has been made to studying cartilaginous neoplasms for two reasons. The first is to better understand the pathobiology of chondrosarcoma and to identify molecular markers to aid in grading and predicting response to treatment. The second is to glean some insights into chondrogenesis. Contemporary molecular biology techniques are being used to clone novel differentially expressed genes from chondrosarcoma cell lines and to characterize their expression in primary tumors. Future efforts will be devoted to determining the function of these genes.
This laboratory is an excellent setting for students, residents, and fellows to obtain training in state of the art research techniques.