Department of Orthopaedics :: Brown Alpert Medical School

Molecular Biology Laboratory - Research

Current / Recent Projects

Molecular analysis of assembly of a novel cartilage matrix protein filamentous network
Investigators: Wang, Z., Chen, Q.

Site-directed mutagenesis of the noncollagenous domain 1 of type X collagen: implication for Schmid type Metaphyseal Chondrodysplasia
Investigators: Zhang, Y., Chen, Q,

Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy
Investigators: Wu, Q., and Chen, Q.

Changes of matrilin forms during endochondral ossification
Investigators: Luo, J., Zhang, Y., and Chen, Q.

Mitogen activated protein kinase p38 mediates inhibition of chondrocyte hypertrophy by parathroid hormone.
Investigators: Wei, L., and Chen, Q.

Osteopontin gene regulation by oscillatory fluid flow via activation of mitogen-activated protein kinase in osteoblasts.
Investigators: You, J., Chen, Q., Donahue, H. J., and Jacobs, C. R

Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation.
Investigators: Yang, X., Wu, Q., Zhang, Y., and Chen, Q.

Interaction of stromal cell-derived factor-1 and CXC chemokine receptor 4 stimulates matrix metalloprotease 3 release from human chondrocytes.
Investigators: Kanbe, K., Takagishi, K., and Chen, Q.

Inhibition of primary osteoarthritis development by inhibition of p38 MAP kinase in a guinea pig model.
Investigators: Wei, L., and Chen, Q.

Blocking of p38 MAPK activity in human chondrocytes inhibits cell death in osteoarthritis
Investigators: Wei, L., Sun, X., and Chen, Q.

P38 MAPK couples chondrocyte hypertrophy to apoptosis during endochondral ossification
Investigators: Wei, L., Sun, X., and Chen, Q.

Molecular lineage selection of osteoprogenitor differentiation into osteoblasts and chondrocytes
Investigators: Wei, L., Sun, X., and Chen, Q.

Identification of molecules that interact with p38 MAPK in chondrocytes by yeast two hybrid system
Investigators: Sun, X., and Chen, Q.

Cloning and characterization of Indian Hedgehog gene promoter
Investigators: Yang, X., Zhang, Y., and Chen, Q.

Changes of IGF-1mRNA levels in the joints of guinea pig during primary osteoarthritis by in situ hybridization
Investigators: Wei, L., and Chen, Q.

Abolishment of endochondral ossification in a p38 MAPK transgenic model
Investigators: Wei, L., and Chen, Q.

Proteolysis of matrilins by extracellular metalloproteinases
Investigators: Wang, Z., and Chen, Q.

Identification and functional analysis of alternative spliced forms of matrilin-2 in cartilage
Investigators: Luo, J., and Chen, Q.

Analysis of matrilin-3 mutants mimicking Multiple Epiphyseal Dysplasia (MED)
Investigators: Kanbe, K., Wei, L., and Chen, Q.

SDF-1 interactions with arthritic chondrocytes induce release of MMP-13 and cell necrosis
Investigators: Wei, L., Sun, X., and Chen, Q.

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residency faculty fellowships research bioengineering cell biology molecular biology research education people contact us links oncology research meetings photo gallery academic calendar Molecular Biology Laboratory - Research Current / Recent Projects Molecular analysis of assembly of a novel cartilage matrix protein filamentous network Investigators: Wang, Z., Chen, Q. Site-directed mutagenesis of the noncollagenous domain 1 of type X collagen: implication for Schmid type Metaphyseal Chondrodysplasia Investigators: Zhang, Y., Chen, Q, Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy Investigators: Wu, Q., and Chen, Q. Changes of matrilin forms during endochondral ossification Investigators: Luo, J., Zhang, Y., and Chen, Q. Mitogen activated protein kinase p38 mediates inhibition of chondrocyte hypertrophy by parathroid hormone. Investigators: Wei, L., and Chen, Q. Osteopontin gene regulation by oscillatory fluid flow via activation of mitogen-activated protein kinase in osteoblasts. Investigators: You, J., Chen, Q., Donahue, H. J., and Jacobs, C. R Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. Investigators: Yang, X., Wu, Q., Zhang, Y., and Chen, Q. Interaction of stromal cell-derived factor-1 and CXC chemokine receptor 4 stimulates matrix metalloprotease 3 release from human chondrocytes. Investigators: Kanbe, K., Takagishi, K., and Chen, Q. Inhibition of primary osteoarthritis development by inhibition of p38 MAP kinase in a guinea pig model. Investigators: Wei, L., and Chen, Q. Blocking of p38 MAPK activity in human chondrocytes inhibits cell death in osteoarthritis Investigators: Wei, L., Sun, X., and Chen, Q. P38 MAPK couples chondrocyte hypertrophy to apoptosis during endochondral ossification Investigators: Wei, L., Sun, X., and Chen, Q. Molecular lineage selection of osteoprogenitor differentiation into osteoblasts and chondrocytes Investigators: Wei, L., Sun, X., and Chen, Q. Identification of molecules that interact with p38 MAPK in chondrocytes by yeast two hybrid system Investigators: Sun, X., and Chen, Q. Cloning and characterization of Indian Hedgehog gene promoter Investigators: Yang, X., Zhang, Y., and Chen, Q. Changes of IGF-1mRNA levels in the joints of guinea pig during primary osteoarthritis by in situ hybridization Investigators: Wei, L., and Chen, Q. Abolishment of endochondral ossification in a p38 MAPK transgenic model Investigators: Wei, L., and Chen, Q. Proteolysis of matrilins by extracellular metalloproteinases Investigators: Wang, Z., and Chen, Q. Identification and functional analysis of alternative spliced forms of matrilin-2 in cartilage Investigators: Luo, J., and Chen, Q. Analysis of matrilin-3 mutants mimicking Multiple Epiphyseal Dysplasia (MED) Investigators: Kanbe, K., Wei, L., and Chen, Q. SDF-1 interactions with arthritic chondrocytes induce release of MMP-13 and cell necrosis Investigators: Wei, L., Sun, X., and Chen, Q.