Molecular Biology Laboratory - People

Lei Wei, M.D., Ph.D.

Molecular Biology Laboratory Coro West, Suite 402 1 Hoppin Street Providence, Rhode Island 02903 Voice: (401) 793-8384 Fax: (401) 444-5872 e-mail: Leiwei43@hotmail.com

Education:
Postdoctoral Training, Penn State University School of Medicine, 2002.
Ph.D. Degree, Karolinska Institute, Stockholm, Sweden 1999.
M.D. Degree, Guiyang Medical College, China, 1983.

Research Focus:
Dr. Lei Wei obtained his M.D. from Guiyang Medical College in China, and his Ph.D. degree from Karolinska Institute in Stockholm, Sweden. Dr. Wei completed his post-doctoral fellowship in Hershey Medical School of Penn State University. Currently, Dr. Wei is an assistant professor in Orthopaedic Research at Brown Medical School/ Rhode Island Hospital.

Dr. Wei's research is supported by NIH grants. Dr. Wei's research interest includes cartilage molecular biology, growth plate development, and osteoarthritis. Throughout Dr. Wei's research career, he received the Scientist Award from New Investigator Recognition Awards (Orthopaedic Research Society 2001), Young Investigator Award (Osteoarthritis Research Society International 2002), and Young Investigator Award, Osteoarthritis Research Society International (OARSI) (2005).

Honors:
New Investigator Recognition Awards (Year 2001 Orthopaedic Research Society).

Osteoarthritis Research Society Internatinal (OARSI) Young Investigator Award (2002).

Selected Publications:
1. Wei, L., Svensson, O. and Hjerpe, A. Correlation of Morphological and Biochemical Changes in the Natural History of the Spontaneous Osteoarthrosis in Guinea Pigs. Arthritis Rheumatism. 1997: 40 (11): 2075-2083.
2. Edin de Bri, Wei, L., Finn P Reinholt, Silwa MW, Dick Heinegard, and Svensson, O. Ultrastructural immunolocalization of bone sioloprotein in guinea pig osteoarthrosis. Osteoarthritis and Cartilage. 1997; 5 (6): 387-393.
3. Wei, L., Svensson, O., and Hjerpe, A. Metabolic Turnover of Sulfated Glycosaminoglycans and Proteoglycans in Guinea Pigs Knee Articular Cartilage during Development of Primary Osteoarthrosis. Osteoarthritis and Cartilage. 1998; 6 (6): 410-416.
4. Wei, L., Lundberg, A., and Svensson, O. Mechanical Load and Primary Guinea Pig Osteoarthrosis. Acta Scandinavica Orthopadica. 1998; 69 (4): 351-357.
5. Edin de Bri, Wei, Lei, Olle Svesson, majeed Chowdhury, Susan A Mooak, and Robert A Greenwald. Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs. Dental Research 1998;vol12:82-85.
6. Edin de Bri and Wei, Lei. Biochemical and histological effects of tetracyclines on spontaneous osteoarthritis in guinea pigs. Image Anal Stereol 2000;19:125-131.
7. Wei, L., Hjerpe, A., and Svensson, O. The effect of load on articular cartilage matrix and the development of osteoarthrosis. Osteoarthritis and Cartilage 2001; 9(5): 447-53.
8. Xuechu Zhen, Lei Wei, Qiuqian Wu, Yue Zhang, and Qian Chen. Mitogen-Activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone. Xuechu Zhen, Lei Wei, Qiuqian Wu, Yue Zhang, and Qian Chen. Journal of Biological Chemistry (JBC). 2001; 276(7): 4879-4885.
9. Wei, L., Hultenby K, Hjerpe, A. Brismar H and Svensson, O. Distribution of chondroitin 4-sulfate epitopes (2/B/6) in spontaneous guinea pig osteoarthrosis. Acta Scandinavica Orthopadica. 2003; 74(1): 16-21.