Molecular Biology Laboratory - People

Qian Chen, Ph.D.

Molecular Biology Laboratory Coro West, Suite 402 1 Hoppin Street Providence, Rhode Island 02903 Voice: (401) 444-6604 Fax: (401) 444-5872 e-mail: Qian_Chen@Brown.edu

Michael G. Ehrlich MD Endowed Chair in Orthopaedic Research
Professor of Medical Science
Director, Center of Biomedical Research Excellence in Skeletal Health and Repair
Department of Orthopaedics
Brown Albert Medical School /Rhode Island Hospital

Dr. Qian Chen was born and raised in Shanghai, China. He obtained his undergraduate degree from Fudan University in China, and his Ph.D. degree from Tufts University School of Medicine in Boston, Massachusetts. Dr. Chen completed his post-doctoral fellowship in Harvard Medical School and Massachusetts General Hospital. Currently, Dr. Chen is Michael G. Ehrlich MD Endowed Chair in Orthopaedic Research and Professor of Medical Science at Brown University. Dr. Chen is the Head of Orthopaedic Biology and Director of Cell and Molecular Biology in the Department of Orthopaedics, Brown Medical School and Rhode Island Hospital. He is the director of Center of Biomedical Research Excellence in Skeletal Health and Repair, a multi-disciplinary translational research center established with more than eleven million dollars by NIH. Dr. Chen's research interest includes cartilage molecular biology, mechanotransduction, and osteoarthritis. Throughout Dr. Chen's research career, he received the Independent Scientist Award from National Institute of Health (NIH), the Satterfield Arthritis Investigator Award from Arthritis Foundation, and the Kappa Delta Award from American Academy of Orthopaedic Surgeons. Dr. Chen has served on NIH study sections and advisory panels, and the merit review panel of the Veterans Administration. He has served as an editor of the journal Current Opinion in Orthopaedics, and Journal of Orthopaedic Surgery and Research. He has been continuously supported by multiple grants from National Institutes of Health for more than a decade.

Graduate Program Affiliations:
Pathobiology, Cell, Molecular Biology and Biochemistry, Bioengineering
Brown University

Education:
Ph.D. Degree, Tufts University School of Medicine, 1992;
Postdoctoral Training, Harvard Medical School and Massachusetts General Hospital, 1992-1994

Honors:
Independent Scientist Award (National Institute of Health)
Kappa Delta Award (American Academy of Orthopaedic Surgeons)
Satterfield Arthritis Investigator Award (Arthritis Foundation)

Selected Publications:

Kanbe, K., Takagishi, K., and Chen, Q. Interaction of stromal cell-derived factor-1 and CXC chemokine receptor 4 stimulates matrix metalloprotease 3 release from human chondrocytes. Arthritis & Rheumatism, 46(1), 130-137, 2002.

Wu, Q., Zhang, Y., and Chen, Q. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J. Biol. Chem., 276(38): 35290-35296, 2001.

You, J., Reilly, G., Zhen, X., Yellowley, C. E., Chen, Q., Donahue, H. J., and Jacobs, C. R.: Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem, 276(16): 13365-13371, 2001.

Zhen, X., Wei, L., Wu, Q., Zhang, Y., and Chen, Q. Mitogen activated protein kinase p38 mediates inhibition of chondrocyte hypertrophy by parathroid hormone. J Biol Chem, 276(7): 4879-4885,2001

Zhang, Y., Chen, Q. Changes of matrilin forms during endochondral ossification: molecular basis of oligomeric assembly. J Biol Chem, 275(42):32628-32634, 2000

Wu, Q., Chen, Q. Mechanoregulation of chondrocyte proliferation, maturation and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp. Cell Res., 256, 383-391, 2000.