Coro West, Suite 402
1 Hoppin Street
Providence, Rhode Island 02903
Voice: (401) 444-6604
Fax: (401) 444-5872
e-mail: Qian_Chen@Brown.edu
Professor of Medical Science
Michael G. Ehrlich Chair in Orthopaedic Research
Department of Orthopaedics
Brown Medical School
Director of Cell and Molecular Biology
Head of Orthopaedic Biology
Rhode Island Hospital
Graduate Program Affiliations:
Pathobiology, Cell, Molecular Biology and Biochemistry, Bioengineering
Brown University
Education:
Ph.D. Degree, Tufts University School of Medicine, 1992;
Postdoctoral Training, Harvard Medical School and Massachusetts General Hospital, 1992-1994
Honors:
Independent Scientist Award (National Institute of Health)
Kappa Delta Award (American Academy of Orthopaedic Surgeons)
Satterfield Arthritis Investigator Award (Arthritis Foundation)
Selected Publications:
Kanbe, K., Takagishi, K., and Chen, Q. Interaction of stromal cell-derived factor-1 and CXC chemokine receptor 4 stimulates matrix metalloprotease 3 release from human chondrocytes. Arthritis & Rheumatism, 46(1), 130-137, 2002.
Wu, Q., Zhang, Y., and Chen, Q. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J. Biol. Chem., 276(38): 35290-35296, 2001.
You, J., Reilly, G., Zhen, X., Yellowley, C. E., Chen, Q., Donahue, H. J., and Jacobs, C. R.: Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem, 276(16): 13365-13371, 2001.
Zhen, X., Wei, L., Wu, Q., Zhang, Y., and Chen, Q. Mitogen activated protein kinase p38 mediates inhibition of chondrocyte hypertrophy by parathroid hormone. J Biol Chem, 276(7): 4879-4885,2001
Zhang, Y., Chen, Q. Changes of matrilin forms during endochondral ossification: molecular basis of oligomeric assembly. J Biol Chem, 275(42):32628-32634, 2000
Wu, Q., Chen, Q. Mechanoregulation of chondrocyte proliferation, maturation and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Exp. Cell Res., 256, 383-391, 2000.