MMI Faculty
Bennett, Richard
Associate Professor of Biology
My laboratory is interested in understanding the biology of the human pathogen Candida albicans. C. albicans is a yeast that grows in the human gastrointestinal tract and is usually harmless to humans. However, in some cases, Candida can cause localized infections in healthy individuals and even life-threatening systemic (bloodstream) infections in immunocompromised individuals. The focus of the laboratory is to understand how Candida acts as a pathogen in humans.
Richard_Bennett@brown.edu
Associate Professor of Biology
My laboratory is interested in understanding the biology of the human pathogen Candida albicans. C. albicans is a yeast that grows in the human gastrointestinal tract and is usually harmless to humans. However, in some cases, Candida can cause localized infections in healthy individuals and even life-threatening systemic (bloodstream) infections in immunocompromised individuals. The focus of the laboratory is to understand how Candida acts as a pathogen in humans.
Richard_Bennett@brown.edu
Biron, Christine
Esther Elizabeth Brintzenhoff Professor of Medical Science
Research in Professor Biron's laboratory is directed at understanding the cellular and cytokine mechanisms regulating immune defenses. There is a particular interest in the responses to acute viral infections and links between innate and adaptive immunity. Basic pathways regulating natural killer (NK) and T cells are being defined. Focus includes regulation of the signal transducers and activators of transcription (STATs).
Christine_Biron@Brown.EDU
Esther Elizabeth Brintzenhoff Professor of Medical Science
Research in Professor Biron's laboratory is directed at understanding the cellular and cytokine mechanisms regulating immune defenses. There is a particular interest in the responses to acute viral infections and links between innate and adaptive immunity. Basic pathways regulating natural killer (NK) and T cells are being defined. Focus includes regulation of the signal transducers and activators of transcription (STATs).
Christine_Biron@Brown.EDU
Brossay, Laurent
Charles A. & Helen B. Stuart Associate Professor of Medical Science
The research in our laboratory is directed at understanding the molecular mechanisms controlling the activation of both NK and NK T cells. These two subsets of cells respond quickly to a stimulus and their activation can determine the outcome of an immune response.
Laurent_Brossay@brown.edu
Charles A. & Helen B. Stuart Associate Professor of Medical Science
The research in our laboratory is directed at understanding the molecular mechanisms controlling the activation of both NK and NK T cells. These two subsets of cells respond quickly to a stimulus and their activation can determine the outcome of an immune response.
Laurent_Brossay@brown.edu
Campbell, Andrew G.
Associate Professor of Medical Science
The research program of the lab involves understanding the fundamental structure and function relationships of RNases H with the long term goals of a) unmasking novel nucleic acid metabolic functions associated with the enzymes and b) understanding their placement in the replicative life cycle of the pathogenic protozoan Trypanosoma brucei. Trypanosomes are amongst the earliest branching eukaryotes and are the models in which RNA editing and trans-splicing were initially discovered. Accordingly, they are well suited for our studies.
Andrew_Campbell@Brown.EDU
Associate Professor of Medical Science
The research program of the lab involves understanding the fundamental structure and function relationships of RNases H with the long term goals of a) unmasking novel nucleic acid metabolic functions associated with the enzymes and b) understanding their placement in the replicative life cycle of the pathogenic protozoan Trypanosoma brucei. Trypanosomes are amongst the earliest branching eukaryotes and are the models in which RNA editing and trans-splicing were initially discovered. Accordingly, they are well suited for our studies.
Andrew_Campbell@Brown.EDU
de Graffenried, Christopher
Assistant Professor of Molecular Microbiology and Immunology
We study the replication of the cytoskeleton in T. brucei, the causative agent of African trypanosomiasis (sleeping sickness) in humans. We have shown that the Polo-like kinase homolog in T. brucei (TbPLK) is essential for the inheritance of the parasite's single flagellum, which is necessary for motility and viability. We focus on understanding how TbPLK affects flagellar inheritance by regulating the duplication and segregation of a suite of cytoskeletal organelles that position the flagellum.
Christopher_DeGraffenried@brown.edu
Assistant Professor of Molecular Microbiology and Immunology
We study the replication of the cytoskeleton in T. brucei, the causative agent of African trypanosomiasis (sleeping sickness) in humans. We have shown that the Polo-like kinase homolog in T. brucei (TbPLK) is essential for the inheritance of the parasite's single flagellum, which is necessary for motility and viability. We focus on understanding how TbPLK affects flagellar inheritance by regulating the duplication and segregation of a suite of cytoskeletal organelles that position the flagellum.
Christopher_DeGraffenried@brown.edu
Jamieson, Amanda
Assistant Professor
The main focus of my laboratory is understanding infectious and non-infectious diseases of the lung, specifically how multiple lung diseases interact and influence each other. Using clinically relevant model systems we examine the impact of the lung microbiome on pulmonary diseases, alterations of the immune response during viral/bacterial coinfection, and the alteration of epithelial cells and tissue repair mechanisms during pulmonary infections, coinfections, and other lung diseases.
Amanda_Jamieson@brown.edu
Assistant Professor
The main focus of my laboratory is understanding infectious and non-infectious diseases of the lung, specifically how multiple lung diseases interact and influence each other. Using clinically relevant model systems we examine the impact of the lung microbiome on pulmonary diseases, alterations of the immune response during viral/bacterial coinfection, and the alteration of epithelial cells and tissue repair mechanisms during pulmonary infections, coinfections, and other lung diseases.
Amanda_Jamieson@brown.edu
Knopf, Paul M.
Charles A. and Helen B. Stuart Professor Emeritus of Medical Science
Prof. Knopf's career interest has been in protein biosynthesis, initially in general but primarily in immunoglobulins and their role as antibodies in humoral immune reponses. Since joining the Brown faculty, he has studied protective antibody responses to worm and protozoan parasitic infections (vaccine development against schistosomiasis and malaria), responses to antigens in the brain (autoimmunity), and most recently the role of complement C3d in the induction of the T-dependent antibody response.
Paul_Knopf@Brown.edu
Charles A. and Helen B. Stuart Professor Emeritus of Medical Science
Prof. Knopf's career interest has been in protein biosynthesis, initially in general but primarily in immunoglobulins and their role as antibodies in humoral immune reponses. Since joining the Brown faculty, he has studied protective antibody responses to worm and protozoan parasitic infections (vaccine development against schistosomiasis and malaria), responses to antigens in the brain (autoimmunity), and most recently the role of complement C3d in the induction of the T-dependent antibody response.
Paul_Knopf@Brown.edu
Mylonakis, Eleftherios
Professor of Medicine; Chief, Infectious Diseases Division
emylonakis@lifespan.org
Professor of Medicine; Chief, Infectious Diseases Division
emylonakis@lifespan.org
Salazar-Mather, Thais
Adjunct Assistant Professor of Molecular Microbiology and Immunology
My laboratory is focused on understanding how immune cells work in concert to eliminate pathogens in infected tissues. Central to this process is the directed migration of activated immune cells into tissues. Our research interests are in two areas: mechanism of regulation and tissue specific functions of cytokines and chemokines and mechanism underlying the effects of chronic alcohol abuse on regulation and tissue specific functions of cytokines and chemokines, during viral infections.
Thais_Mather@Brown.EDU
Adjunct Assistant Professor of Molecular Microbiology and Immunology
My laboratory is focused on understanding how immune cells work in concert to eliminate pathogens in infected tissues. Central to this process is the directed migration of activated immune cells into tissues. Our research interests are in two areas: mechanism of regulation and tissue specific functions of cytokines and chemokines and mechanism underlying the effects of chronic alcohol abuse on regulation and tissue specific functions of cytokines and chemokines, during viral infections.
Thais_Mather@Brown.EDU
Shank, Peter
Professor of Medical Science
Our laboratory has worked on the regulatory genes of HIV-1. We were particularly interested in understanding the mechanism of action of the tat regulatory gene. Tat is unique among transcriptional activators in that the gene product interacts with a secondary structural element at the 5' at the end of the RNA transcript. We are also interested in the role of HIV in malignancy, particularly B-cell lymphomas. We have shown that HIV can infect human B-cells in a CD4 independent manner.
Peter_Shank@Brown.EDU
Professor of Medical Science
Our laboratory has worked on the regulatory genes of HIV-1. We were particularly interested in understanding the mechanism of action of the tat regulatory gene. Tat is unique among transcriptional activators in that the gene product interacts with a secondary structural element at the 5' at the end of the RNA transcript. We are also interested in the role of HIV in malignancy, particularly B-cell lymphomas. We have shown that HIV can infect human B-cells in a CD4 independent manner.
Peter_Shank@Brown.EDU
Wands, Jack
Professor of Medicine
Jack Wands directs the Liver Research Center, a newly constructed 13,000-sq. ft. facility that emphasizes studies relating to the molecular biology of liver diseases.
Jack_Wands_MD@Brown.EDU
Professor of Medicine
Jack Wands directs the Liver Research Center, a newly constructed 13,000-sq. ft. facility that emphasizes studies relating to the molecular biology of liver diseases.
Jack_Wands_MD@Brown.EDU