Dr. Jason Aliotta is an Assistant Professor of Medicine and a clinician in the Division of Pulmonary, Sleep and Critical Care Medicine. He is also a K08-funded investigator in the Division of Hematology/Oncology where his research focuses on the mechanism of bone marrow stem cell production of lung cells in various murine lung injury models. In particular, he has an interest in lung-derived microvesicles as phenotypic modifiers of marrow cells and as mediators of cell-to-cell communication.

Biography

Dr. Aliotta attended Tufts Medical School and completed a Residency in Internal Medicine at the Beth Israel Deaconess Medical Center in Boston, MA. He then completed a Fellowship in Pulmonary and Critical Care Medicine at the Warren Alpert Medical School of Brown University. Dr. Aliotta joined the faculty of Rhode Island Hospital and the Miriam Hospital in 2006 as a clinician, primarily as an Intensivist, and an investigator in the Center for Stem Cell Biology Research. In 2008, Dr. Aliotta became the Associate Program Director of the Pulmonary and Critical Care Medicine Fellowship and was awarded a 5-year K08 though the NIH.

Awards

-Dean's Teaching Excellence Award, Pulmonary Pathophysiology Small Group, The Warren Alpert Medical School of Brown University, 2007 and 2008
-Elected Fellow of the American College of Chest Physicians (FCCP) 2008

Affiliations

-American College of Chest Physicians, 2002-present
-Society of Critical Care Medicine, 2002-present
-American Thoracic Society, 2003-present
-International Society for Experimental Hematology, 2004-present

Funded Research

-NIH, New Stem Cell Biology COBRE (Subproject: Bone Marrow Derived Stem Cell Homing and Lung Cell Production in Injured Lung). Grant Amount: $13,283,625. 2003-2008
-NIH, Cell Cycle Related Transdifferentiation into Lung Cells. Grant Amount: $1,775,900. 2003-2008
-NIH, Injured Lung and its Influence on Bone Marrow Cell Phenotype. Grant Amount: $634,365. 2008-2012

Teaching Experience

-Small Group Discussion Leader, Pulmonary Pathophysiology, The Warren Alpert Medical School of Brown University

Selected Publications

• Dooner MS*, Aliotta JM*, Pimentel J, Dooner GJ, Abedi M, Colvin GA, Liu Q, Weier HU, Johnson KW, Quesenberry PJ. Cell cycle related differentiation of bone marrow cells into lung cells. Stem Cell Dev. 2008;17(2):207-20. *Equal Contributions(2008)
• Quesenberry PJ and Aliotta JM. The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches and microvesicles. Stem Cells Reviews. 2008 Jul 30. [Epub ahead of print](2008)
• Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K. The Stem Cell Continuum: Cell Cycle, Injury, and Phenotype Lability. Ann N Y Acad Sci. 2007;1106:20-9.(2007)
• Puente N, Aliotta JM, Passero MA. Update on idiopathic pulmonary fibrosis: the role of gamma interferon and cytokines. Med Health RI. 2007;90(2):43-45.(2007)
• Aliotta JM, Sanchez-Guijo FM, Dooner GJ, Johnson KW, Dooner MS, Greer KA, Greer D, Pimentel J, Kolankiewicz LM, Puente N, Faradyan S, Ferland P, Bearer EL, Passero MA, Adedi M, Colvin GA, Quesenberry PJ. Alteration of marrow cell gene expression, protein production and engraftment into lung by lung-derived microvesicles: A novel mechanism for phenotype modulation. Stem Cells. 2007;25(9):2245-56.(2007)
• Aliotta JM, Keaney P, Passero M, Dooner MS, Pimentel J, Greer D, Demers D, Foster B, Peterson A, Dooner G, Theise ND, Adedi M, Colvin GA, Quesenberry PJ. Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation and subpopulation phenotype. Exp Hematol. 2006;34(2):230-41.(2006)
• Quesenberry PJ, Abedi M, Dooner M, Colvin G, Sanchez-Guijo FM, Aliotta J, Pimentel J, Dooner G, Greer D, Demers D, Keaney P, Peterson A, Luo L, Foster B. The marrow cell continuum: stochastic determinism. Folia Histochem Cytobiol. 2005;43(4):187-90.(2005)
• Quesenberry PJ, Colvin GA, Abedi M, Dooner G, Dooner M, Aliotta J, Keaney P, Luo L, Demers D, Peterson A, Foster B, Greer D. The stem cell continuum. Ann N Y Acad Sci. 2005;1044:228-35.(2005)
• Aliotta JM, Passero MA, Meharg J, Klinger J, Dooner MS, Pimentel J, Quesenberry PJ. Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration. J Cell Physiology. 2005;204(3):725-41.(2005)
• Quesenberry PJ, Abedi M, Aliotta J, Colvin G, Demers D, Dooner M, Greer D, Hebert H, Menon MK, Pimentel J, Paggioli D. Stem cell plasticity: an overview. Blood Cells Mol Dis. 2004;32(1):1-4.(2004)
• Colvin GA, Lambert JF, Abedi M, Dooner MS, Demers D, Moore BE, Greer D, Aliotta JM, Pimentel J, Cerny J, Lum LG, Quesenberry PJ. Differentiation hotspots: the deterioration of hierarchy and stochasm. Blood Cells Mol Dis. 2004;32(1):34-41.(2004)
• Xu S, Xiao J, Ettwiller R, Holden M, Aliotta J, PohY C, Dalton M, Robinson DP, Petronzio TR, Moran LS, Ganatra M, Ware JL, Slatko B, Benner JS. Cloning and characterization of ApaLI, NspI, NspHI, SacI, ScaI and SapI restriction-modification systems in Escherichia coli. Molecular and General Genetics. 1998; 260(2-3): 226-231.(1998)
• Sears LE, Zhou B, Aliotta JM, Morgan RD, Kong H. BaeI, another unusual BcgI-like restriction endonuclease. Nucleic Acids Research. 1996; 24(18): 3590-3592.(1996)
• Aliotta JM, Pelletier JJ, Ware JL, Moran LS, Benner JS, Hong H. Thermostable Bst DNA polymeraseI lacks 3'-->5' proofreading exonuclease activity. Genetic Analysis. 1996; 12(5-6): 185-195.(1996)