Dr. Daley's interests focus on the process of tissue repair following injury. Tissue healing requires a series of well coordinated events involving different types of cells. Dr. Daley's research focuses on the characteristics, functions, and interactions of the neutrophils and macrophages which participate in the repair process. An understanding of these cellular functions and cellular interactions may suggest opportunities for therapeutic intervention in impaired healing.

Biography

Dr. Jean Daley is a graduate of Bowdoin College and Tufts University School of Medicine. She completed a residency in General Surgery and a Research Fellowship in Surgery at Brown University and Rhode Island Hospital. She is presently Assistant Professor of Surgery (Research). Her research focuses on the phenotypic and functional characteristics of neutrophils and macrophages in a mouse model of tissue injury.

Research Description

Tissue healing requires a series of well coordinated events involving different types of cells. Studies in the laboratory focus on the phenotypic and functional profiles of wound neutrophils and wound macrophages. We have observed that wound neutrophils have the capacity to influence macrophage phenotype and function. Ongoing studies focus on the heterogeneity of macrophage populations in the wound, researching the origins and functional consequences of macrophage diversity in the wound environment.

Awards

National Research Service Award (NIH), 1987-1989
Department of Surgery, Rhode Island Hospital

Haffenreffer Fellowship Award, 1989
Department of Surgery, Rhode Island Hospital

Affiliations

American College of Surgeons, Fellow
Association of Women Surgeons
Rhode Island Medical Women's Association
Society for Leukocyte Biology
American Society for Investigative Pathology

Funded Research

Current funding:
1. "Heterogeneity of wound macrophages", Principal Investigator
Principal Investigator: Jean M. Daley
Grant #K08GM079227 NIH
Total Costs: $607,365
April 1, 2007 – March 31, 2012

Previous funding:
1. "Cellular/molecular biology of inflammation and repair", Co-investigator
Principal Investigator: Jorge E. Albina, MD
Grant #R01GM 42859, NIH
Total Costs: $1,324,400
March 1, 2006 through March 31, 2007
2. "Phenotypic Characterization of Wound Neutrophils", Principal Investigator
Principal Investigator: Jean M. Daley, MD
Grant #20050238, Rhode Island Foundation
Amount: $10,000
January 1, 2005 through December 31, 2005

3. "Supplement to Promote Reentry into Biomedical and Behavioral Research Careers", Investigator
Principal Investigator: Jorge E. Albina, MD
Supplement to Grant # RO1GM 42859, NIH
Total Costs: $315,364
June 1, 2002 through February 28, 2006

View My Full Publication List in pdf format