Our Laboratory for Restorative Neurotechnology focuses on developing strategies to restore communication, mobility, and independence for people with paralysis or limb loss. In addition to endeavors related to the pilot clinical trial of the BrainGate2 Neural Interface System, we are interested in understanding human intracortical neurophysiology during the planning and production of voluntary movement, and understanding neuronal ensemble function in a variety of neurologic diseases or injuries.

Institutions

Brown Me

Research Description

Clinical Interests
Stroke
Neurocritical Care

Translational Neuroscience Interests
Brain-Computer Interfaces
Neurotechnology

Funded Research

Rehabilitation Research and Development Service, Department of Veterans Affairs
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Child Health and Human Development / National Center for Medical Rehabilitation Research (NICHD/NCMRR)
Doris Duke Charitable Foundation
Deane Institute

Selected Publications

• Hochberg, L.R. Turning thoughts into action. N Engl J Med. 2008; 359(11): 1175-7.(2008)
• Truccolo W., Friehs G.M., Donoghue J.P., Hochberg L.R. Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia. Journal of Neuroscience, 2008; 28(5);1163-1178.(2008)
• Kim, S-P., Simeral, J.D., Hochberg, L.R., Donoghue, J.P., Friehs, G.M., and Black, M.J. Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia. IEEE Engineering in Medicine and Biology International Conference on Neural Engineering. 2007; 486-489.(2007)
• Donoghue, J.P., Black, M., Nurmikko, A., and Hochberg, L.R. Assistive technology and robotic control using MI ensemble-based neural interface systems in humans with tetraplegia. Journal of Physiology. 2007; March 15; 569(3) p. 603-11.(2007)
• Donoghue, J.P., Hochberg, L.R., Nurmikko, A.V., Black, M.J., Simeral, J.D., and Friehs, G. Neuromotor Prosthesis Development. RI Medicine and Health. 2007; 90(1);12-15(2007)
• Aaron R.K., Herr H.M., Ciombor D.M., Hochberg L.R., Donoghue J.P., Briant C.L., Morgan J.R., Ehrlich M.G. Horizons in prosthesis development for the restoration of limb function. J Am Acad Orthop Surg. 2006; 14(10):S198-204.(2006)
• Hochberg LR, Donoghue J.P. Sensors for brain-computer interfaces. IEEE Eng Med Biol Mag. 2006; 25(5):32-8.(2006)
• Kubler A, Mushahwar VK, Hochberg LR, Donoghue JP. BCI Meeting 2005--workshop on clinical issues and applications. In: IEEE Trans Neural Syst Rehabil Eng; New York; June 2006. p. 131-4.(2006)
• Hochberg L.R., Serruya MD, Friehs G.M., Mukand J.A., Saleh M., Caplan A.H., Branner A., Chen D., Penn R.D., Donoghue J.P. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature. 2006; 442(7099):164-71.(2006)
• Hochberg L.R., Sims J.R., Davis B.T. West Nile encephalitis in Massachusetts. N Engl J Med. 2002; 346(13):1030-1.(2002)
• Burrow, M., Dugger, J., Humphrey, D.R., Reed, D.J., and Hochberg, L.R. Cortical control of a robot using a time-delay neural network. In: Proceedings of the Fifth International Conference on Rehabilitation Robotics; 1997.(1997)
• Humphrey, D.R., and Hochberg, L.R. Intracortical recording of brain activity for control of limb prostheses. In: Proceedings of the Rehabilitation Engineering Society of North America; Vancouver, Canada: RESNA; 1995. p. 650-658.(1995)