Jeanne McCaffery's research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: environmental contributions of socioeconomic status to health behaviors and cardiovascular disease, and DNA variation that predicts depression and physiological responses to psychological stress and DNA variation that predicts ability to lose weight.

Biography

Jeanne McCaffery, PhD, is an Associate Professor of Psychiatry and Human Behavior at The Miriam Hospital and The Warren Alpert School of Medicine at Brown University. She received her PhD in Clinical and Health Psychology at the University of Pittsburgh and completed her clinical internship at the Brown University Clinical Psychology Training Consortium in 2001. She received The Bruce M. Seyla for Research Excellence from Lifespan Hospitals in 2009 and the Award for Outstanding Contributions to Health Psychology, Junior Division from the American Psychological Association, Division 38 (Health Psychology) in 2011. Her research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: environmental contributions of socioeconomic status to health behaviors and cardiovascular disease, genetic variation that contributes to depression among cardiac patients and genetic variation that contribute to the ability to lose weight. She has published over fifty empirical articles and has served a principal investigator or co-investigator on multiple grant awards from the National Institutes of Health.

Institutions

MH

Research Description

Jeanne McCaffery's research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: environmental contributions of socioeconomic status to health behaviors and cardiovascular disease, and DNA variation that predicts depression and physiological responses to psychological stress and DNA variation that predicts ability to lose weight.

Awards

Honors

Award for Outstanding Contributions to Health Psychology, Junior Division from the American Psychological Association, Division 38 (Health Psychology), 2011
The Bruce M. Seyla for Research Excellence from Lifespan Hospitals, 2009
Student Travel Award, American Psychosomatic Society, 2001
Student Research Award, American Psychological Association (APA), Division 38 (Health Psychology),2000
Huey Award for Dissertation Research in Clinical Psychology, University of Pittsburgh, 2000
Bassell Award for Excellence in Clinical Psychology Graduate Studies, University of Pittsburgh, 2000
Colavita-Weisburg Award for Excellence in Health Psychology Graduate Studies, University of Pittsburgh, 2000
University of Pittsburgh - Carnegie Mellon University Health Psychology Predoctoral Fellow, University of Pittsburgh, 1999-2000
Cardiovascular Behavioral Medicine Predoctoral Fellow, University of Pittsburgh, 1995-1999

Affiliations

· Member, The Obesity Society, 2005 - present.
· Member, APA, Division 38 (Health Psychology), 2000-present
· Member, American Psychological Association (APA), 1999-present
· Member, American Psychosomatic Society, 1996-present

Funded Research

ACTIVE GRANTS

Ongoing support

5 U01 DK056992-13 (Wing) 9/30/99 – 7/31/13
Study of Health Outcomes of Weight Loss-SHOW Trial
The purpose of this study is to investigate the health outcomes of long-term weight loss and maintenance.
5 U01 CA150387-03 (Wing) 9/28/09 – 8/31/14
Increasing Sleep Duration: A Novel Approach to Weight Control
The primary goal of this grant is to translate basic science on sleep and obesity to clinical intervention.
3 U01 DK056992-13S1 (McCaffery, Wing) 8/1/09 – 7/31/13
Gene X Behavior Interaction in the Look AHEAD Study
The primary goal of this grant is the identify genetic markers that interact with a behavioral weight loss treatment to predict the extent of weight loss.
5 R01 AG018384-09 (Lyons) 8/15/08 – 8/31/13
The VETSA Longitudinal Twin Study of Cognition and Aging
The primary goal of this grant is to study genetic and environmental contributions to change in cognitive function.
5 R01 NS052470 (Paul) 7/1/07 – 6/30/12
NINDS
Neuromarkers of Age-Related Cognitive Decline
This grant is designed to examine genetic and MRI predictors of cognitive decline.
5 P01 HL040962-19 (Manuck) 9/7/07 – 1/31/13
Biobehavioral Studies of Cardiovascular Disease
This grant is designed to examine the biobehavioral predictors of cardiovascular risk factors and disease.
1 R01 DK090043-01 (McCaffery) 3/1/11 – 2/28/14
Genetics and Behavioral Effects on High-Density Lipoprotein: The Look AHEAD Study
This grant will examine whether genetic markers associated with high-density lipoprotein cholesterol alter the impact of behavioral weight loss intervention on high-density lipoprotein cholesterol.
X01 HG006659 (McCaffery, Huggins) 12/1/11 – 11/30/12
Genetic and Behavioral Effects on High-Density Lipoprotein: The Look AHEAD Study.
This grant is designed to genotype more than 200,000 single nucleotide polymorphism related to cardiovascular disease, serum lipids and related traits in the Look AHEAD cohort.

Completed support
Department of Psychiatry (McCaffery) 9/1/07 – 8/31/09 (no cost extension)
Brown Medical School
Endothelial Mechanisms of Depression in Heart Disease
This grant evaluates endothelial mechanisms as predictors of depression in cardiac patients.
P50 CA084719 (Niaura) 9/30/99-7/31/09
NCI
Nicotine Dependence: Phenotype, Endophenotype & Contexts
This grant is designed to examine genetic and environmental predictors of nicotine dependence.
R01 DK066787 (Wing) 1/1/05 – 12/31/08 (no cost extension)
NIDDK
Long-term Weight Loss Maintenance: Functional Imaging
This grant examines fMRI BOLD response in brain regions related reward among people who have lost weight and maintained the weight loss and obese and normal weight controls.

Teaching Experience

· Course Director, T32 Post-doctoral Seminar Series in Cardiovascular Behavioral Medicine, Centers for Behavioral and Preventive Medicine, Brown Medical School, 2005 – present.

· Seminar Instructor, "Behavioral genetics in behavioral medicine", Brown Clinical Psychology Internship Behavioral Medicine Seminar Series, Brown Medical School, 2001 - present.

· Faculty mentor, Brown Undergraduate Teaching and Research Assistantship awarded to Aimee Two for her project, "STOP! smoking: magazine based intervention to promote smoking cessation among college students", 2004.

· Faculty mentor, Research Internship, Aimee Two, Brown Medical School, 2003-2004. Research training involved the administration of clinical diagnostic interviews and statistical analysis.

· Course Instructor/Teaching Fellow, Undergraduate Abnormal Psychology, University of Pittsburgh, 1999

Selected Publications

• Alosco, M.L., Benitez, A., Gunstad, J., Spitznagel, M.B., McCaffery, J.M., McGeary, J.E., Poppas, A., Paul, R.H., Sweet, L.H., & Cohen, R.A. (in press). Reduced memory in Fat Mass and Obesity Associated (FTO) allele carriers among older adults with cardiovascular disease. Psychogeriatrics.(IN PRESS)
• McCaffery, J.M., Papandonatos, G.D., Peter, I., Huggins, G.S., Raynor, H.A., Delahanty, L.M., Cheskin, L.J., Balasubramanyam, A. Wagenknecht, L.E., Wing, R.R. (in press). Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. American Journal of Clinical Nutrition.(IN PRESS)
• Sweet, L.H., Hassenstab, J., McCaffery, J.M., Haley, A.P., Bond, D., Raynor, H.A., Del Parigi, A., Cohen, R., Wing, R.R. (in press). Brain response to food stimulation in obese, normal weight, and successful weight loss maintainers. Obesity.(IN PRESS)
• Peter I., McCaffery J.M., Kelley-Hedgepeth A., Hakonarson H., Reis S., Wagenknecht L.E., Kopin A., Huggins G.S., for the Genetics Subgroup of the Look AHEAD Study (2012). Association of Type 2 Diabetes Susceptibility Loci with One-Year Weight 1 Loss in the Look AHEAD Clinical Trial. Obesity. Feb 6. doi: 10.1038/oby.2012.11. [Epub ahead of print](2012)
• Delahanty, L.M., Pan, Q., Jablonski, K.A., Watson, K.E., McCaffery, J.M., Shuldiner, A., Kahn, S.E., Knowler, W.C., Florez, J.C., Franks, P.W. (2012). Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program. Diabetes Care, 35(2):363-6.(2012)
• Saxena, R., Elbers, C.C. …McCaffery, J., … Keating, B.J. (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. American Journal of Human Genetics, 90(3):410-425.(2012)
• Smart-Halajko, M.C., Kelley-Hedgepeth, A., Montefusco, M.C., Cooper, J.A., Kopin, A., McCaffery, J.M., Balasubramanyam, A., Pownall, H.J., Nathan, D.M., Peter, I., Talmud, P.J. & Huggins, G.S. (2011). ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial BMC Medical Genetics, 12:89.(2011)
• McCaffery, J.M., Jablonski, K.A., Franks, P.W., Dagogo-Jack, S., Wing, R.R., Knowler, W.C., Delahanty, L., Dabelea, D., Hamman, R., Shuldiner, A.R., & Florez, J.C. (2011). TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the Diabetes Prevention Program. PLoS One, 6(7):e21518.(2011)
• McCaffery, J.M., Franz, C.E., Jacobson, K., Leahey, T.M., Xian, H., Wing, R.R., Lyons, M.J. & Kremen, W.S. (2011). Effects of social contact and zygosity on 21-year weight change in male twins. American Journal of Clinical Nutrition, 94(2):404-9.(2011)
• Phelan, S., Hassentaub, J., McCaffery, J.M., Sweet L., Raynor H.A., Cohen R.A. & Wing R.R. (2011). Cognitive Interference From Food Cues in Weight Loss Maintainers, Normal Weight, and Obese Individuals. Obesity, 19(1):69-73.(2011)
• Scherrer, J.F., Xian, H., Lustman, P.J., Franz, C.E., McCaffery, J., Lyons, M.J., Jacobson, K.C., Kremen W.S. (2011). A test for common genetic and environmental vulnerability to depression and diabetes. Twin Research and Human Genetics, Apr;14(2):169-72(2011)
• Miller, L.A., Gunstad, J., Spitznagel, M.B., McCaffery, J., McGeary, J., Poppas, A., Paul, R.H., Sweet, L.H., & Cohen, R.A. (2011). CAMTA1 T polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease. Psychogeriatrics, 11(3):135-40.(2011)
• Marsland A.L., McCaffery J.M., Muldoon M.F. & Manuck S.B. (2010). Systemic inflammation and the metabolic syndrome among middle-aged community volunteers. Metabolism, 59(12):1801-8.(2010)
• Xian, H., Scherrer, J.F., Franz, C.E., McCaffery, J., Stein, P.K., Lyons, M.J., Jacobsen, K., Eisen, S.A., Kremen, W.S. (2010). Genetic Vulnerability and Phenotypic Expression of Depression and Risk for Ischemic Heart Disease in the Vietnam Era Twin Study of Aging. Psychosomatic Medicine, 72(4):370-5.(2010)
• Bond D.S., Raynor H.A., McCaffery J.M., Wing R.R. (2010). Salivary habituation to food stimuli in successful weight loss maintainers, obese and normal-weight adults. International Journal of Obesity, 34(3), 593-6.(2010)
• McCaffery, J.M., Papandonatos, G.D., Bond, D., Lyons, M.J. & Wing, R.R. (2009). Gene x environment interaction of vigorous exercise and body mass index among male Vietnam-era Twins. American Journal of Clinical Nutrition, 89(4), 1011-8.(2009)
• McCaffery, J.M., Haley, A., Sweet, L., Phelan, S., Raynor, H. Del Parigi, S., Cohen, R.A., Wing, R.R. (2009). Differential fMRI response to food pictures in successful weight-loss maintainers relative to normal-weight and obese controls. American Journal of Clinical Nutrition, 90(4), 928-34.(2009)
• Gunstad, J., Benitez, A., Hoth, K., Spitznagel, M., McCaffery, J., McGeary, J., Kakos, L., Poppas, A., Paul, R., Jefferson, A.L., Sweet, L., & Cohen, R. (2009). P-selectin 1087G/A polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease. Stroke, 40(9), 2969-72.(2009)
• McCaffery, J.M., Papandonatos, G.P., Lyons, M.J., & Niaura, R. (2008). Educational attainment and the heritability of self-reported hypertension in Vietnam-era twins. Psychosomatic Medicine,70, 781-786.(2008)
• McCaffery, J.M., Duan, Q-L, Frasure-Smith, N., Barhdadi, A., Lespérance, F., Théroux, P., Rouleau, G.A., Dubé, M-P. (2008). Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics, Part B, July 10 (e-pub).(2008)
• McCaffery, J.M., Papandonatos, G.P., Stanton, C., Lloyd-Richardson, E.E., & Niaura, R. (2008). Depressive symptoms and cigarette smoking in twins from the National Longitudinal Study of Adolescent Health. Health Psychology, 27, (3 supplement), S207-215.(2008)
• Wing, R.R., Papandonatos, G.D., Fava, J.L., Gorin, A.A., Phelan, S., McCaffery, J.M., Tate, D.F. (2008). Maintaining large weight losses: The role of behavioral and psychological factors. Journal of Consulting and Clinical Psychology, 76(6), 1015-21.(2008)
• Otte, C., McCaffery, J., Ali, S. & Whooley, M.A. (2007). Association of serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: The Heart and Soul Study. American Journal of Psychiatry, 164 (9), 1379-84.(2007)
• Duan, Q.L., Dubé, M-P., Frasure-Smith, N., Barhdadi, A., Lesperance, F., Théroux, P., Saint-Onge, J., Rouleau, G.A., & McCaffery, J.M. (2007). Obesity and TCF7L2 variants increase risk for type 2 diabetes among cardiac patients. Diabetes Care, 30(6), 1621-3.(2007)
• David SP, Brown RA, Papandonatos GD, Kahler CW, Lloyd-Richardson EE, Munafò MR, Shields PG, Lerman C, Strong D, McCaffery J, Niaura R. (2007). Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine and Tobacco Research, 9, 821-33.(2007)
• McCaffery, J.M., Shen, B-J, Niaura, R., Muldoon, M.F. & Manuck, S.B. (2007). Ambulatory blood pressure and the metabolic syndrome in normotensive and untreated hypertensive men. Metabolic Syndrome and Related Disorders, 5, 34-44.(2007)
• McCaffery, J.M., Papandonatos, G.P., Lyons, M.J., Koenen, K., Purcell, S., & Niaura, R. (2007). Education attainment, smoking initiation and lifetime nicotine dependence among male Vietnam-era twins. Psychological Medicine, 38, 1287-97.(2007)
• Cohen RA, Paul RH, Stroud L, Gunstad J, Hitsman BL, McCaffery J, Sweet L, Niaura R, MacFarlane A, Bryant RA, Gordon E. (2006). Early life stress and adult emotional experience: an international perspective. International Journal of Psychiatry in Medicine, 36, 35-52.(2006)
• Peterson, K.L., Bleil, M.E., McCaffery, J.M., Mackey, R.H., Sutton-Tyrell, K., Muldoon, M.F. & Manuck, S.B. (2006). Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive men. American Journal of Hypertension, 19(6), 560-6.(2006)
• Cohen, R.A., Grieve, S., Hoth, K.F., Paul, R.H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitaman, B., Niaura, R., Clark, C.R., MacFarlane, A., Bryant, R., Gordon, E. Williams, L.M. (2006). Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biological Psychiatry, 59 (10), 975-82.(2006)
• Koenen, K.C., Hitsman, B., Lyons, M.J., Stroud, L., Niaura, R., McCaffery, J., Goldberg, J., Eisen, S.A., True, W., Tsuang, M. (2006). Posttraumatic stress disorder and late-onset smoking in the Vietnam era twin registry. Journal of Clinical and Consulting Psychology, 74 (1) 186 - 90.(2006)
• Zhang, J., Niaura, R., Todaro, J.F., McCaffery, J.M., Shen, B.J., Spiro, A., Ward, K.D. (2006). Hostility and urine norepinephrine interact to predict insulin resistance: The VA Normative Aging Study. Psychosomatic Medicine, 68, 718-726.(2006)
• Zhang, J., Niarua, R., Todaro, J.F., McCaffery, J.M., Shen, B.J., Spiro, A., Ward, K.D. (2005). Suppressed hostility predicted hypertension incidence among middle-aged men: The Normative Aging Study. Journal of Behavioral Medicine, 23, 1-12.(2005)
• Rende, R. Slomkowsky, C., McCaffery, J., Lloyd-Richardson, E.E., Niaura, R. (2005). A twin-sibling study of tobacco use etiology in adolescence: Etiology of individual differences and extreme scores. Nicotine and Tobacco Research, 7, 413-419.(2005)
• Koenen, K.C., Hitsman, B., Lyons, M.J., Niaura, R., McCaffery, J., Goldberg, J., Eisen, S.A., Tsuang, M. (2005). A twin registry study of the relationship between nicotine dependence and posttraumatic stress disorder. Archives of General Psychiatry, 62, 1258-1265.(2005)
• Bleil, M.E., McCaffery, J.M., Muldoon, M.F., Sutton-Tyrrell, K., Manuck, S.B. (2004). Anger-related personality traits and carotid artery atherosclerosis in untreated hypertensive men. Psychosomatic Medicine, 66, 633-639.(2004)
• McCaffery, J.M., Bleil, M., Pogue-Geile, M.F., Ferrell, R.E. & Manuck, S.B. (2003). Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins. Psychosomatic Medicine, 65, 721-728.(2003)
• McCaffery, J.M., Niaura, R., Todaro, J.F., Swan, G. & Carmelli, D. (2003). Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung and Blood Institute Twin Study. Psychosomatic Medicine, 65, 490-497.(2003)
• Shen, B.J., Todaro, J.F., Niaura, R., McCaffery, J.M., Zhang, J., Spiro, A., & Ward, K.D. (2003). Are metabolic risk factors one unified syndrome? -- Modeling the structure of the metabolic syndrome X. American Journal of Epidemiology, 157, 701-711.(2003)
• McCaffery, J.M., Niaura, R., Swan, G. & Carmelli, D. (2003). A study of depressive symptoms and smoking behavior in adult male twins from the NHLBI twin study. Nicotine and Tobacco Research, 5, 77-83.(2003)
• Gianaros, P. J., Bleil, M. E., Muldoon, M. F., Jennings, J. R., McCaffery, J. M., Sutton-Tyrrell, K. C., & Manuck, S. B. (2002). Is cardiovascular reactivity associated with atherosclerosis among hypertensives? Hypertension, 40, 742 - 747.(2002)
• McCaffery, J.M., Pogue-Geile, M.F., Ferrell, R.E., Petro, N. & Manuck, S.B. (2002). Variability in alpha- and beta-adrenergic receptor genes as a predictor of cardiovascular function at rest and in response to psychological challenge. Journal of Hypertension, 20, 1105-1114.(2002)
• Raynor, D.A., Pogue-Geile, M.F., Kamarck, T.W., McCaffery, J.M., & Manuck, S.B. (2002). Covariation of psychosocial characteristics associated with cardiovascular disease: genetic and environmental influences. Psychosomatic Medicine, 64, 191-203.(2002)
• McCaffery, J.M., Pogue-Geile, M.F., Muldoon, M.F., Debski, T.T., Wing, R.R., & Manuck, S.B. (2001). The nature of the association between diet and serum lipids in the community: a twin study. Health Psychology, 20, 341-350.(2001)
• McCaffery, J.M., Muldoon, M.F., Bachen, E.A., & Manuck, S.B. (2000). Behaviorally-evoked plasma catecholamine response and 24-hour excretion of urinary catecholamine among cardiac and vascular reactors. Biological Psychology, 52, 53-69.(2000)
• McCaffery, J.M., Pogue-Geile, M.F., Debski, T.T. & Manuck, S.B. (1999). Genetic and environmental causes of covariation among serum lipids, blood pressure and body mass during young adulthood: A twin study. Journal of Hypertension, 17, 1677-1685.(1999)
• Greenberg, D., McCaffery, J., Potack, J.Z., Bray, G.A. & York, D.A. (1999). Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. Physiology and Behavior, 66, 621-626.(1999)
• Manuck, S.B., Flory, J.D., McCaffery, J.M., Matthews, K.A., Mann, J.J. & Muldoon, M.F. (1998). Aggression, impulsivity and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology, 19, 287-29.(1998)
• Manuck, S.B., Adams, M.R., McCaffery, J.M. & Kaplan, J.R (1997). Behaviorally elicited heart rate reactivity and atherosclerosis in ovariectomized cynomolgus monkeys (Macaca fascicularis). Arteriosclerosis, Thrombosis and Vascular Biology, 17, 1774-1779.(1997)