Environmental toxicants are ubiquitous in nature and the effects of early embryonic exposure are a public health concern. The focus of my research is on the characterization of known environmental pollutants on early embryonic development of the central nervous system. Currently, we are investigating the neurodevelopmental effects of embryonic exposure to PCB 52, PCB 105, and PCB 153, which have been documented to co-exist in the environment and are found contaminating homes on Cape Cod, MA.

Biography

July 2006 – present, Assistant Professor of Biology (Research), Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island

Jan 2005-June 2006 Adjunct Lecturer, Brown University School of Medicine, Department of Molecular Microbiology and Immunology, Providence, Rhode Island

Dec 1999-Aug 2005 Investigator, Brown University School of Medicine, Department of Obstetrics and Gynecology, Women and Infants Hospital, Providence, Rhode Island

1996-1999 Postdoctoral Fellow, Marine Biological Laboratory, Woods Hole, Massachusetts

1995-1996 Postdoctoral Fellow, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York

PhD 1994 West Virginia University School of Medicine, Morgantown, West Virginia.

B.S. 1988 Kent State University, Kent, Ohio

Institutions

Wih

Awards

Reviewer for W. W. Norton, 2006
Reviewer for Microscopy and Research Technique, 2000.
Reviewer for The Biological Bulletin, 1997.

Keck Fellowship. Albert Einstein College of Medicine, Bronx, NY, 1995.
Zeiss Summer Fellowship. Marine Biological Laboratory. Woods Hole, MA, 1993.
Scholarship Microbial Diversity Course, Marine Biological Laboratory, Woods Hole, 1993.
Invited participant at the NIH Conference on Lyme Disease, Cold Spring Harbor, NY. 1993.
American Society for Microbiology Allegheny Branch, 2nd place in research competition, 1992.
Graduated Summa Cum Laude with Departmental Honors, Kent State University, 1988.
Phi Beta Kapp, Kent State University. Awarded in junior year. 1987.

Funded Research

Pilot Project, Kreiling (PI) 1/08 – 4/08
RI-INBRE P20RR016457 to URI (NCRR)
The effects of early embryonic exposure to PCB on the developing nervous system.
Role: Principal Investigator

Teaching Experience

Introductory Microbiology

Courses Taught

• Introductory Microbiology (BI0051)

Selected Publications

• Kreiling J.A., Balantac Z.L, Toure J,., Zchut S., Kochilas L., and Creton R. 2008. Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain. Mech Dev. 125(5-6):396-410. Epub 2008 Feb 20.(2008)
• Kreiling J.A., Creton R.J., Reinisch C.L. 2007. Early Embryonic Exposure to PCBs Disrupts Heat Shock Protein 70 Cognate Expression in Zebrafish Embryos. J Tox Envir Health, part A. 70(12):1005-13.(2007)
• Kreiling J.A., Prabhat, Williams G., and Creton R. 2007. Analysis of Kupffer's Vesicle in Zebrafish Embryos using a Cave Automated Virtual Environment. Dev Dyn. 236(7):1963-9. May 14; (Epub ahead of print).(2007)
• Dewilde, S, B. Ebner, E. Vinck, K. Gilany, T. Hankeln, T. Burmester, J. Kreiling, C. Reinisch, J. Vanfleteren, L. Kiger, M.C. Marden, C. Hundahl, A. Fago, S. Van Doorslaer, L. Moens. 2006. The nerve hemoglobin of the bivalve mollusc Spisula solidissima: Molecular cloning, ligand binding studies and phylogenetic analysis. J Biol Chem. Mar 3;281(9):5364-5372. Epub 2005 Dec 13.(2006)
• Kreiling, J.A., R.E. Stephens, C.L. Reinisch. 2005. A Mixture of Environmental Contaminants Increases PKA-RII expression in Spisula embryo. Environ Tox Pharm 19: 9-18.(2005)
• Jessen-Eller, K., J. Kreiling, G.S. Begley, M.E. Steele, C.W. Walker, R.E. Stephens, C.L. Reinisch. 2002. A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls. Environ Health Perspect 110:377-85.(2002)
• Kreiling J.A., K. Jessen-Eller, J. Miller, R.F. Seegal, C.L. Reinisch. 2001. Early Development of the Serotonergic and Dopaminergic Nervous System in Spisula solidissima (surf clam) Larvae. Comp Biochem Physiol A Mol Integr Physiol 130:341-51.(2001)
• Creton, R., J. Kreiling, L. Jaffe. 2000. Presence and Roles of Calcium Gradients along the Dorsal-Ventral Axis in Drosophila Embryos. Developmental Biology. 217: 375-385.(2000)
• Kreiling, J.A., R. Stephens, A.M. Kuzirian, K. Jessen-Eller, C.L.Reinisch. 2000. Polychlorinated Biphenyls are Selectively Neurotoxic to the Developing Spisula Solidissima Embryo. . Tox Envir Health, part A 61: 101-119.(2000)
• Kreiling, J., R. Duncan, M., Faggart, N. Cornell.1999. Comparison of the Beluga Whale (Delphinapterus leucas) Expressed Genes for 5-aminolevulinate Synthase with Those in Other Vertebrates. Comp Biochem Physio, part B 123:163-174.(1999)
• Creton, R., J. Kreiling, L. Jaffe. 1999. Calcium Imaging with Luminescent Indicators. Microscopy Research and Technique 46:390-397.(1999)
• Srimal, S., J. Kreiling, J. Quigley, P. Armstrong, N. Wainwright. 1996. Antimicrobial Activity of Limulus Blood: Role of C-Reactive Protein (CRP) and Limulus Anti-Lipopolysaccharide Factor (LALF). Biol Bull 191: 300-301.(1996)
• Goldstein,S., N. Charon, J. Kreiling. 1994. Borrelia burgdorferi Swims with a Planar Waveform Similar to those of Eukaryotic Flagella. Proc Nat Acad Sci 91: 3433-37.(1994)
• Charon, N., S. Goldstein, S. Block, K. Curci, J. Ruby, J. Kreiling, R. Limberger. 1992. Morphology and Dynamics of Protruding Spirochete Periplasmic Flagella. J Bacteriol 174: 832-840.(1992)
• Stevenson, J., J. Kreiling, R. Taylor. 1989. Effects of Corticosterone on Responses of Murine Splenic B and T Cells to Phytohemagglutinin, Concanavalin A, and Lipopolysaccharide. Immun Invest 18: 951-960.(1989)