Cancer treatment using image-guided techniques such as radiofrequency ablation, cryoablation and microwave ablation: These methods are used to destroy solid tumors in lung, liver, kidney, adrenal, and bone in patients who are poor candidates for conventional treatments such as surgery, chemotherapy, and radiation. These image-guided ablative methods can also be used in conjunction with standard therapies to improve cancer control.

Biography

Dr Dupuy, is the director of Tumor Ablation at Rhode Island Hospital and a professor of Diagnostic Imaging at Brown Medical School.
Dr. Dupuy, a pioneer in the use of image-guided ablation, helped broaden clinical applications to successfully combat cancer involving the kidney, liver, lung, adrenal, head and neck and skeleton. Other newer technologies such as microwave ablation, and combination therapies using RFA with external radiation or brachytherapy have been pioneered by Dr. Dupuy who has been the principal investigator of two NCI funded multicenter trials.
Dr. Dupuy has published over 140 publications and given over 110 invited lectures in the field of radiology and image-guided ablation.

Institutions

Rih

Research Description

Healing with Heat

A new kind of cancer treatment is helping many who cannot benefit from more traditional therapies. Radiofrequency ablation (RFA) is a minimally invasive technique that uses heat to destroy tumors. Using CT scan or ultrasound guidance, a small needle electrode is placed directly into the tumor. The electrode's high frequency electrical current creates intense heat that can reach the boiling point of water, killing cancerous cells. Radiofrequency ablation using the current technology was approved by the Food and Drug Administration (FDA) in October 1997. Since then, a number of hospitals around the country have adopted the technique, most often to destroy liver tumors.

At Rhode Island Hospital, we have taken RFA a step further by broadening its application. RFA has been used successfully to combat breast, kidney, liver, lung, adrenal,head and neck and bone cancer. In the years following FDA approval, more than 2000 patients have undergone radiofrequency ablation here. To date this is the largest use of RFA in treating malignancy in North America. Radiofrequency ablation takes between 45 and 90 minutes and can be performed with intravenous sedation. The procedure creates a small incision that only requires a band-aid, and because heat cauterizes the area, no bleeding has been reported. It can be done safely on an outpatient basis.

RFA is less traumatic than surgery, so it is an alternative for older patients, those who are frail or patients who have medical conditions that exclude surgery as an option. It has also been used successfully when treatments such as radiation or chemotherapy fail. Age is no barrier to eligibility; my patients have ranged in age from 6 months to 92. Unlike radiation, RFA does not adversely affect the immune system. Patients can receive more than one RFA treatment, if necessary.

Awards

1988 Honorable Mention American Gastroenterological Association
Research Abstract Competition

1992 Elected Chief Resident, Department of Radiology
Deaconess Hospital, Harvard Medical School

1993 Bronze Medal 93rd American Roentgen Ray Society
Annual Meeting, San Francisco, California

1994 Honorable Mention, 94th American Roentgen Ray Society
Annual Meeting, New Orleans, Louisiana,

1999 Magna Cum Laude, 85th Scientific Assembly and Annual
Meeting of the Radiological Society of North America

2000 Certificate of Merit, 100th Annual meeting American Roentgen
Ray Society

2001 Cum Laude 87th Scientific Assembly and Annual Meeting of the
Radiological Society of North America

2002 Magna Cum Laude 87th Scientific Assembly and Annual Meeting
of the Radiological Society of North America

2002 Design Award 89th Scientific Assembly and Annual
Meeting of the Radiological Society of North America

2003 Honorary Degree, Master of Arts, Ad Eundum, Brown University

2004 Certificate of Merit, 90th Scientific Assembly and Annual
Meeting of the Radiological Society of North America

2007 Voted One of America's Best Doctors

2009 Fellow, American College of Radiology

2010 American College of Radiology Imaging Network (ACRIN)
Publications Merit Award

Affiliations

1985-Present Phi Beta Kappa
1989-Present Radiological Society of North America
1995-Present American College of Radiology
1995-Present New England Roentgen Ray Society, Inc.
1997-Present Society of Radiologists in Ultrasound
1997-Present American Medical Association
1997-Present Rhode Island Medical Society
1997-Present Rhode Island Radiologic Society
1998-Present American Roentgen Ray Society
1998-Present American Institute of Ultrasound in Medicine
2003-Present American College of Surgeons Oncology Group
2007-Present American Society of Clinical Oncology

Funded Research

Principal Investigator
PERCUTANEOUS RADIOFREQUENCY ABLATION OF PAINFUL OSSEOUS METASTATIC DISEASE USING CT GUIDANCE
Radionics Corporation, Burlington, MA; $50,000; 1999-2001.

Principal Investigator
RADIOFREQUENCY ABLATION FOLLOWED BY CONVENTIONAL THERAPY FOR INOPERABLE NON-SMALL CELL LUNG CANCER
Valleylab Inc.; $60,000; 2002-2004.

Principal Investigator
TISSUE HARMONICS IMAGING IN ABDOMINAL ULTRASOUND
GE Medical, Milwaukee, WI; $30,000; 1998-1999.

Principal Investigator
A PHASE I/II STUDY OF PERCUTANEOUS RADIOFREQUENCY ABLATION OF BONE METASTASES USING CT GUIDANCE
Multi-institutional grant, National Cancer Institute through American College Of Radiology Imaging Network, ACRIN 6661; $186,000; 2002-2004.

Principal Investigator
MICROWAVE ABLATION OF HEPATIC TUMORS; AN ABLATE AND RESECT TRIAL
Vivant Medical, Mountain View, CA; $20,000; 2003-2004.

Principal Investigator
MICROWAVE ABLATION OF LUNG TUMORS; AN ABLATE AND RESECT TRIAL
Vivant Medical, Mountain View, CA; $10,000; 2003-2004.

Principal Investigator
RADIOFREQUENCY ABLATION FOLLOWED BY HIGH DOSE RATE BRACHYTHERAPY FOR STAGE 1A NSCLC
Valleylab Inc.; $30,000; 2004.

Principal Investigator
MICROWAVE ABLATION OF LUNG TUMORS; AN ABLATE AND RESECT TRIAL
Vivant Medical, Mountain View, CA; $40,000; 2004.

Principal Investigator
A PILOT STUDY OF RADIOFREQUENCY ABLATION IN HIGH-RISK PATIENTS WITH STAGE IA NON-SMALL CELL LUNG CANCER
Submitted ACOSOG multi-center trial, 4/14/2006; Project funded and approved with enrollment beginning summer 2006.

Principal Investigator
UTILITY OF AN ELECTROMAGNETIC TRACKING DEVICE FOR CT-GUIDED INTERVENTIONAL PROCEDURES
Sponsored by Veran Medical Technologies; $50,000; IRB approved awaiting equipment installation on 5/18/2006.

Co-Investigator
PERCUTANEOUS US AND CT-GUIDED CRYOABLATION OF PAINFUL METASTASES INVOLVING BONE: A FEASABILITY STUDY
Multicenter trial sponsored by Endocare, Inc.; $3,000/patient; Principal Investigator: Matthew Callstrom, Mayo Clinic, Rochester, MN.

Co-Investigator
ACRIN 6673: MULTICENTER FEASABILITYSTUDY OF PERCUTANEOUS RADIOFREQUENCY ABLATION OF HEPATOCELLULAR CARCINOMA IN CIRRHOTIC PATIENTS.
Sponsored by ACRIN and NCI. February 2006; $45,000

Principal Investigator
LASER ABLATION OF BENIGN SYMPTOMATIC THYROID MASSES
Sponsored by Biotex. March 2007; $60,000

Principal Investigator
UTILITY OF AN ELECTROMAGNETIC TRACKING DEVICE FOR
CT-GUIDED BIOPSY OF SMALL LUNG LESIONS: A RANDOMIZED TRIAL COMPARED WITH CONVENTIONAL CT
Sponsored by Veran Medical Technologies. $50,000

Co-Investigator
FDA TRIAL TO EVALUATE SAFETY AND EFFICACY OF LUNG SEALANT (PNEUMOSEAL)AT REDUCING PNEUMOTHORAX FROM CT-GUIDED BIOPSY
Sponsored by PneumRX, August 2007; 1,000/patient

Co-Investigator
RANDOMIZED TRIAL OF PAIN PALLIATION FOR SOLITARY PAINFUL BONE METASTASES BETWEEN CRYOABLATION AND CONVENTIONAL RADIOTHERAPY (CARE TRIAL)
Sponsored by NCI. January 2008; 6,000/patient
PI: Matthew Callstrom, Mayo Clinic, Rochester, MN

Principal Investigator
LUNG IRREVERSIBLE ELECTROPORATION IN THE PORCINE MODEL
Sponsored by Angiodynamics, Glenns Falls, NY $60,000

Principal Investigator
MICROWAVE ABLATION OF LUNG TUMORS; AN ABLATE AND RESECT TRIAL
Sponsored by Medwaves, San Diego, CA $30,000 2009

Teaching Experience

629 – Preceptorship in Diagnostic Radiology
1997-Present
Provide overview of diagnostic ultrasound in clinical practice by didactic conferences showing live video and current clinical material. Day to day teaching in ultrasound demonstrating role in clinical practice, teaching imaging anatomy, and demonstrating image-guided intervention.

633 – Cross Sectional Imaging in Clinical Medicine
1997-Present
One on one interaction with students illustrating the utility of CT, US and MRI in body imaging. Case presentations at cross-sectional imaging conference, case report presentations and research encouraged. Direct hands-on experience and teaching provided for paracentesis and thoracentesis using ultrasound guidance.

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