Publications

2012

Desai HV, Voruganti IS, Jayasuriya C, Chen Q, Darling EM. Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells. Tissue Eng A. doi: 10.1089/ten.TEA.2012.0127.(2012)

Beane OS, Darling EM. Isolation, Characterization, and Differentiation of Stem Cells for Cartilage Regeneration. Ann Biomed Eng. doi: 10.1007/s10439-012-0639-8. PMCID: PMC3457050.(2012)

Gonzalez-Cruz RD, Darling EM. Adipose-derived stem cell fate is predicted by cellular mechanical properties. Adipocyte. In press.(2012)

Gonzalez Cruz RD, Fonseca VC, Darling EM. Celluar mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells. PNAS, May 2012. 1120349109v1-7. (2012)

Desai HV, Darling EM. Force Scanning for Simultaneous Collection of Topographical and Mechanical Properties. Microscopy and Analysis, January 2012. Volume 26, Issue 1.(2012)

2011

Darling EM. Force scanning: A rapid, high-resolution approach for spatial mechanical property mapping. Nanotechnology, 22 (2011) 175707.(2011)

2010

Yim EKF, Darling EM, Kulangara K, Zauscher S, Guilak F and Leong KW. Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials, 31 (2010) pp. 1299-1306, PMID: 19879643.(2010)

Darling EM*, Wilusz RE*, Bolognesi MP, Zauscher S, and Guilak F. Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. Biophys J, 98 pp. 2848-2856.(2010)

2009

Darling EM, Pritchett PE, Evans BA, Superfine R, Zauscher S, Guilak F. Mechanical properties and gene expression of chondrocytes on micropatterned substrates following dedifferentiation in monolayer. Cell Molec Bioeng, 2 (3) pp. 395-404.(2009)

Athanasiou KA, Darling EM, Hu JCY. Articular Cartilage Tissue Engineering. Morgan & Claypool Publishers: San Rafael, CA.(2009)

2008

Darling EM, Topel M, Zauscher S, Vail TP, Guilak F. Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. J Biomech, 41 (2) pp. 454-464, PMID: 17825308.(2008)

Coles J, Blum J, Jay G, Darling EM, Guilak F, Zauscher S. In situ friction measurement on murine cartilage by atomic force microscopy. J Biomech, 41 (3) pp. 541-548, PMID: 18054362.(2008)

Darling EM, Guilak F. A neural network model for cell classification based on single-cell biomechanical properties. Tissue Eng Part A, 14 (9) pp. 1507-1515, PMID: 18620486.(2008)

2007

Darling EM, Zauscher S, Block JA, Guilak F. A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: Do cell properties reflect metastatic potential? Biophys J, 92 pp. 1784-1791, PMID: 17158567.(2007)

2006

Darling EM, Zauscher S, Guilak F. Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. Osteoarthritis Cartilage, 14 (6) pp. 571-579, PMID: 16478668.(2006)

2005

Darling EM, Athanasiou KA. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res, 23 (2) pp. 425-432, PMID: 15734258.(2005)

Darling EM, Athanasiou KA. Retaining zonal chondrocyte phenotype by means of novel growth environments. Tissue Eng, 11 (3/4) pp. 395-403, PMID: 15871669.(2005)

Darling EM, Athanasiou KA. Growth factor impact on articular chondrocyte subpopulations. Cell Tissue Res, 322 pp. 463-473, PMID: 16047167.(2005)

2004

Darling EM, Athanasiou KA. Bioactive scaffold design for articular cartilage engineering. Biomedical Technology and Devices Handbook. Ed. by J. Moore and G. Zouridakis. Chapter 21, CRC Press: Boca Raton, FL.(2004)

Darling EM, Hu JCY, Athanasiou KA. Zonal and topographical gene expression in articular cartilage. J Orthop Res, 22 (6) pp. 1182-1187, PMID: 15475195.(2004)

2003

Darling EM, Athanasiou KA. Articular cartilage bioreactors and bioprocesses. Tissue Eng, 9 (1) pp. 9-26, PMID: 12625950.(2003)

Darling EM, Athanasiou KA. Biomechanical strategies for articular cartilage regeneration. Ann Biomed Eng, 31 pp. 1114-1124, PMID: 14582614.(2003)