Analysis of Mesenchymal Stem Cell Sources in Rattus rattus

Investigator: Olivia Beane

Mesenchymal stem cells (MSCs) are an attractive cell source for tissue engineering and cell-based regeneration therapies. They are found in most tissues throughout the body and possess the ability to differentiate into multiple lineages. To assess the therapeutic potential of these adult stem cells, cell yield, senescence, proliferation rate, multipotential differentiation, and viability are typically evaluated. Previous studies have shown variation in individual parameters among gender, tissue source, and pregnancy. However, a comprehensive assessment in a single donor is necessary to determine their relative importance. The objective of this study is to determine the therapeutic potential of MSCs with respect to gender, source tissue, and pregnancy using a rat model.