Title: Osteoarthritis Following ACL Reconstruction
Summary: One of the goals of anterior cruciate ligament reconstruction is to prevent the progression of arthritis commonly seen in the ACL-deficient knee. However, there is some clinical evidence to suggest that post-traumatic arthritis will persist following surgery. The objective of this investigation is to evaluate the progression of osteoarthritis following ACL reconstruction using an experimental model. The status of the articular cartilage of the knee will be assessed in control, sham, ACL-deficient and ACL-reconstructed knees. Articular cartilage damage will be quantified by assessing the mechanical properties of tissue.
Funding: Supported by The National Institute of Health (NIH)
Summary: The initial tension applied to the graft at the time of surgery affects the knee motion and the distribution of contact stress, factors thought to promote osteoarthritis in the ACL-injured knee. The objective of this study is to evaluate the effects of initial graft tension on the articular cartilage following ACL reconstruction in a prospective, double-blinded, randomized, and controled study. Articular cartilage status is being assessed by measuring changes in the joint spaces of the tibiofemoral joint. Secondary outcomes include changes in joint kinematics, strength and patient-oriented outcomes.
Funding: Supported by The National Institute of Health (NIH)
Summary: Biomarkers of articular cartilage metabolism (biochemical markers of collagen and aggrecan synthesis and degradation) may serve as surrogates for articular cartilage damage. However, longitudinal studies are needed to relate the changes in concentrations the biochemical markers, which are obtained from serum, synovial fluid, and/or cartilage samples, to the status of articular cartilage. Using the experimental model described above, the relationship between the biomarkers and the material properties of the articular cartilage following ACL injury and treatment are being ascertained.
Funding: National Football League Charities
Summary: The objective of this study is to measure the ACL strain response during rehabilitation exercises and other muscle-induced loading conditions in human subjects.
Funding: National Football League Charities
Summary: The objective of this investigation was to develop an experimental model to evaluate different parameters of ACL reconstruction on graft healing and the progression of OA.
Funding: Supported by The National Institute of Health (NIH)