1999 Reading List

Pfizer - Bio 154A (Molecular Genetics)

Lecture:

1. Sep. 8 Introduction

Chapter 1 Establishing the role of genes within cells

Chapter 2 DNA is the primary genetic material

Chapter 3 Elucidation of the genetic code

Chapter 4 The genetic elements that control gene expression

Hannah's Heirs Prologue

" " The Life and Death of Hannah

" " Gregor Mendel

Racing... Beginnings

2. Sep. 15 Chapter 8 The complexity of the genome

Chapter 9 Controlling eukaryotic gene expression

Chapter 5 Methods of creating recombinant DNA molecules

Chapter 7 The isolation of cloned genes

Hannah's Heirs Alois Alzheimer

" " The Descendants of Hannah and Shlomo

" " Mendel's Heirs

Racing... Internal Combustion

Cohen et al., (1973) PNAS, 70, 3240-3244.

Durkop et al., (1992) Cell, 68, 421-427.

3. Sep. 22 Chapter 7 The isolation of cloned genes

Chapter 6 The polymerase chain reaction

Hannah's Heirs Alzheimer's Disease at Midcentury

" " Enter Genetics

" " New Seeds are Sown

Racing... Smoke and Mirrors

Stamenkovic et al., (1990) J. Exp. Med., 172, 641-643.

Digweed & Sperling, (1996) BioEssays, 18, 579-585.

Strathdee et al., (1992) Nature, 356, 763-767.

Mullis, K., (1990) Sci. Amer., April, 56-65.

4. Sep. 29 Chapter 6 The polymerase chain reaction

Chapter 11 In vitro mutagenesis

Hannah's Heirs No Longer Alone

" " Twin Pillars of Hope

" " A Transmissible Virus?

Racing... A Can of Worms

Marx, J., (1993) Science, 260, 751-752.

Peltomaki et al., (1993) Science, 260, 810-812.

Aaltonen et al., (1993) Science, 260, 812-816.

Radman & Wagner, (1993) Nature, 366, 722.

Fishel et al., (1993) Cell, 75, 1027-1038.

Leach et al., (1993) Cell, 75, 1215-1225.

Bonner et al., (1994) Nature, 368, 258-261.

Papadopoulos et al., (1994) Science, 263, 1625-1629.

Nicolaides et al., (1994) Nature, 371, 75-80.

Southgate & Green, (1991), Genes Dev., 5, 2496-2507.

5. Oct. 6 Chapter 11 In vitro mutagenesis-2

Chapter 12 Transferring genes into mammalian cells

Chapter 13 Using yeast to study eukaryotic gene function-1: complementation

Hannah's Heirs Base Camp, Circa 1980

" " The New Basis for Linkage Maps of the Human Genome

" " The Quest for the Huntington's Gene

Racing... Stamping Out Cancer

Southgate & Green, (1991), Genes Dev., 5, 2496-2507. (cont.)

Wagner, R., (1994), Nature, 372, 333-335.

Rosner et al., (1991) Cell, 64, 1103-1110.

Xiong et al., (1991) Cell, 65, 691-699.

6. Oct. 13 Chapter 13 Using yeast to study eukaryotic gene function-2: two hybrid system

Chapter 16 Molecules of immune recognition - 1: V(D)J recombination/RAG-1

Hannah's Heirs Charles

" " Peter St. George-Hyslop and the Link to Chromosome 21

Racing... Unconventional Backwardness

Chien et al., (1991) PNAS, 88, 9578-9582.

Fields & Sternglanz, (1994) TIGS, 10, 286-292.

Mendelsohn & Brent, (1999) Science, 284, 1948-1950

Schatz et al., (1989) Cell, 59, 1035-1048.

7. Oct. 20 Chapter 16 Molecules of immune recognition-2: RAG-1

------------- Sex determination-1

Hannah's Heirs A Gene for Amyloid

" " A Seige of the Soul

Racing... Very Special Cancer Viruses

Schatz et al., (1989) Cell, 59, 1035-1048. (cont.)

Oettinger et al., (1990) Science, 248, 1517-1523.

Jimenez et al., (1996) TIGS, 12, 164-166.

Page et al., (1987) Cell, 51, 1091-1104.

8. Nov. 3 ------------- Sex determination-2

Chapter 14 The introduction of foreign genes into mice: Transgenics

Chapter 14 The introduction of foreign genes into mice: Knockouts-1

Hannah's Heirs Elizabeth W. and the Second Family from Bobruisk

" " A Unity of Heart and Mind

Racing... California Viruses

" " The Revolution of '76

Palmer et al., (1989) Nature, 342, 937-939.

Koopman et al., (1989) Nature, 342, 940-942.

Sinclair et al., (1990) Nature, 346, 240-244.

Gibbons, A., (1997) Science, 278, 804-805.

Koopman et al., (1991), Nature, 351, 117-121.

Levin, M., (1997), BioEssays, 19, 287-296.

Belmonte, J., (1999) Sci. Amer., 280, 46-51.

Yokoyama et al., (1993), Science, 260, 679-682.

9. Nov. 10 Chapter 14 The introduction of foreign genes into mice:Knockouts

Chapter 14 The intro. of foreign genes into mice: Cell Type-Specific Knockouts

Hannah's Heirs Russia Once Again

" " The Twenty-one Pedigrees of Nina Ivanova Voskresenskaya

Racing... Transmitted in Error

" " Genes Bearing Gifts

Shinkai et al., (1992), Cell, 68, 855-867.

Baringa, M., (1992) Science, 257, 162-163.

Takahashi et al., (1994) Science, 264, 1724-1733.

Roush, W., (1997) Science, 275, 32-33.

Silva et al., (1992) Science, 257, 206-211.

Chen et al., (1994) Science, 266, 291-294.

Baringa, M., (1994) Science 265, 26-28.

Gu et al., (1994) Science 265, 103-106.

10. Nov. 17 Chapter 29 Studying whole genomes

Chapter 26 Mapping and cloning human disease genes

Hannah's Heirs How Many Genes?

" " The Third Dove Goes Forth

Racing... Picking Up the Pieces

" " Shilo's Cane

Schlessinger, D., (1990) TIGS, 6, 248-258.

Capecchi, M., (1993) Nature, 362, 205-206.

Jakobovits et al., (1993) Nature, 362, 255-258.

Green & Olson, (1990) Science, 250, 94-98.

Sutherland et al., (1998) TIGS, 14, 501-506.

Verkerk et al., (1991) Cell, 65, 905-914.

11. Nov. 24 Chapter 26 Mapping and cloning human disease genes

Hannah's Heirs Lost Tribes

" " The First Abnormal Gene is Found

Racing... A Horse Race

" " Hidden Connections

Goodfellow, P., (1993) Cell, 72, 817-818.

Huntington's Group, (1993) Cell, 72, 971-983.

Warren, S., (1996) Science 271, 1374-1375.

Mandel, J.-L., (1997) Nature 386, 767-769.

Wooster & Stratton, (1995) TIGS, 11, 3-5.

Miki et al., (1994) Science, 266, 66-71.

Chen et al., (1995) Science, 270, 789-791.

Wooster et al., (1994) Science, 265, 2088-2090.

Wooster et al., (1995) Nature, 378, 789-792.

Marx, J., (1997) Science, 276, 531-532.

Kinzler & Vogelstein, (1997), Nature, 386, 761-762.

12. Dec. 1 Chapter 26 Mapping and cloning human disease genes

Hannah's Heirs New Sightings

" " Mutual Aid as a Factor in Evolution and in Genetic Research

Racing... A Three-Ring Circus

" " The Cornell Minicomputer

Chagnon & Bouchard, (1996) TIGS, 12, 441-444.

Zhang et al., (1994) Nature, 372, 425-432.

Baringa, M., (1995) Science, 269, 475-476.

Selkoe, D., (1997) Science, 275, 630-631.

Schellenberg et al., (1992) Science, 258, 668-671.

Sherrington et al., (1995) Nature, 375, 754-760.

Welsh & Smith, (1993) Cell, 73, 1251-1254.

Boucher, R., (1996) TIGS, 12, 81-84.

Rosenfeld et al., (1992) Cell, 68, 143-155.

Hyde et al., (1993) Nature, 362, 250-255.

Zhou et al., (1994) Science, 266, 1705-1708.

13. Dec. 8 Chapter 28 Working toward human gene therapy

Chapter 30 The human genome initiative-Finding all the human genes

Hannah's Heirs Hannah's Heirs

" " Landfall

Racing... A Hundred Years War

" " Out of Dark Woods

Oliver et al. (1992) Nature, 357, 38-46.

Wilson et al. (1994) Nature, 368, 32-38.

Vollrath et al. (1992) Science, 258, 52-59.

Foote et al. (1992) Science, 258, 60-66.

Miklos & Rubin, (1996) Cell, 86, 521-529.

Schuler et al., (1996) Science, 274, 540-546.

Goffeau et al., (1996) Science, 274, 546-567.

Rowan et al., (1997) Science, 278, 605-607.

Marshall, E., (1999) Science, 284, 1906-1909.

14. Dec. 15 FINAL EXAM