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Introduction

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Sources of Cells

Patients and Donors

HLA Matching & Complications

Transplant Procedure

Cost & Demographics

Future Applications

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On this page:
Cost of a Hematopoietic Stem Cell Transplant
Cost of Donating or Storing Hematopoietic Stem Cells
Number of Hematopoietic Stem Cell Transplants
Survival Rates

Cost of a Hematopoietic Stem Cell Transplant

On average, the cost of a hematopoietic stem cell transplant is about $100,000 - $250,000, although some transplant centers quote prices as low as $85,000.The cost of a hematopoietic stem cell transplant varies considerably at different transplant centers and depending on the patient’s age, type of cancer, hospital stay, and other factors.Most insurance companies cover most of the cost of a bone marrow transplant. Advances in treatment methods, including the use of PBSCT, have reduced the amount of time many patients must spend in the hospital by speeding recovery. This shorter recovery time has brought about a reduction in cost. However, because BMT and PBSCT are complicated technical procedures, they are very expensive. Many health insurance companies cover some of the costs of transplantation for certain types of cancer. Insurers may also cover a portion of the costs if special care is required when the patient returns home.

 

Cost of Donating or Storing Hematopoietic Stem Cells

People willing to donate bone marrow or peripheral blood stem cells (PBSC’s) must have a sample of blood drawn to determine their HLA type. This blood test usually costs $65 to $96. The donor may be asked to pay for this blood test, or the donor center may cover part of the cost. Community groups and other organizations may also provide financial assistance. Once a donor is identified as a match for a patient, all of the costs pertaining to the retrieval of bone marrow or PBSCs is covered by the patient or the patient’s medical insurance.

A woman can donate her baby’s umbilical cord blood to public cord blood banks at no charge. However, commercial blood banks do charge varying fees to store umbilical cord blood for the private use of the patient or his or her family.

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Private cord blood banks usually charge an enrollment and collection fee of about $600 to $1,900, plus annual storage fees ranging from about $80 to $100.

 

Number of Hematopoietic Stem Cell Transplants

On average there are around 20,000 hematopoietic stem cell transplants in the United States each year.  Roughly 2/3 of these transplants are autologous transplants, while allogeneic transplants constitute the remaining1/3.

70 percent of those needing a BMT using donor marrow are unable to have one because a suitable bone marrow donor cannot be found.

 

Survival Rates

Survival rates after a hematopoeitic stem cell transplant vary depending on many factors including patient age, type of cancer, stage of cancer, and response to other treatments.

  • Approximately 25-50% of bone marrow transplant recipients develop long-term complications.
  • Approximately 30% of people receiving allogeneic transplants do not survive.
  • Autologous transplants have a much better survival rate-nearly 90%-but are not appropriate for all types of ailments requiring a bone marrow transplant.

Five-Year Survival Data by Disease


Disease

Survival Rate %

Autologous Transplantation

Allogeneic Transplantation

Sibling Donor

Unrelated Donor

Acute Lymphoblastic Leukemia

N/A

55-65%

35-45%

Acute Myelogenous Leukemia

40-60%
(20% with no remission)

45-65%

30-50%

Chronic Myeloid Leukemia

N/A

60-70%

50-55%

Hodgkin Disease

70-80%

N/A

N/A

Diffuse Large-cell Lymphoma

50-65%

20-25%

30%

Neuroblastoma

40%

N/A

N/A


Causes of Death after Hematopoietic Stem Cell Transplant

HLA IDENTICAL SIBLING

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Relapse – 38%
Infection – 17%
GVHD – 14%
Other –13 %
Organ Toxicity – 13 %
IPn 5%

UNRELATED

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Relapse – 32%
Infection – 19%           
GVHD – 14%
Other –17 %
Organ Toxicity – 11%
IPn (7%)

AUTOLOGOUS

pie3

Relapse – 75%
GVHD – 14%
Other –9 %
Infection – 6%
IPn (2%)