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10th International Symposium on Blood Substitutes

Contents

1. Interesting Links
2. Picture Credits
3. Website References

Interesting Links (top)

Most Interesting
1. No Blood, Medicine Meets the Challenge (Video clip, Jehovah's Witnesses): http://www.watchtower.org/library/vcnb/article_01.htm
2. Blood Substitutes, Brown University, 2000: http://biomed.brown.edu/Courses/BI108/BI108_2000_Groups/Blood_Substitutes/

Relevant
Alliance Pharmaceutical Corp.: http://www.allp.com/
Bloodless Medicine Research: http://www.med.unipi.it/patchir/bloodl/bmr.htm
Perftoran: http://www.perftoran.ru/Eng/index.php?newlang=english
Sanguine Corp.: http://www.sanguine-corp.com/default.htm
Synthetic Blood International, Inc.: http://www.sybd.com/
Biospace breaking news: http://www.biospace.com/

Picture Credits (top)

All picture credits are listed in order of appearance.

Intro
1. Brand new idea cartoon: http://www.synnovation.co.za/Images/cartoon.gif
2. Hemoglobin: http://www.chem.purdue.edu/chm333/hemoglobin.JPG

History
1. Cows: http://www.cias.wisc.edu/wsbdf/cows.jpg
2. Sir Christopher Wren: http://www.arct.cam.ac.uk/personal-page/james/phd/wren/
3. Oxyglobin for dogs: http://www.fmshk.com.hk/hkabth/ss/Haemoglobin-Based%20Oxygen%20Carriers%20for%20Anaemia(200311).pdf

Opinions
1. Expensive cartoon: http://www.heroinhelper.com/images/Expensive_Hospital_Stay.jpg
2. Safe Blood for Africa: http://www.exxonmobilafrica.com/Images/PA/Africa/SafeBloodSignBldg-courtesySFBA.jpg

PFCs
1. PFCE Patricle: http://www.allp.com/Oxygent/ox_fact.htm
2. Production: http://www.allp.com/Oxygent/ox_fact.htm
3. PFC size: http://www.allp.com/Oxygent/ox_fact.htm
3. Capillary: http://www.allp.com/Oxygent/ox_fact.htm
4. Oxygent: http://www.allp.com/Oxygent/ox_fact.htm
5. Augmented-ANH: http://www.allp.com/Oxygent/ox_fact.htm
6. Mouse immersed in PFCs: http://www.ho.chiba-u.ac.jp/emccm/m4/
7. Capillary plaque: http://www.allp.com/Oxygent/ox_fact.htm

HBOCs
1. Hemoglobin: Biopure Corporation; www.biopure.com
2. Bag of Biopure: Biopure Corporation; www.biopure.com
3. Overview: Kim and Greenburg; http://www.blackwell-synergy.com/links/doi/10.1111/j.1525-1594.2004.07345.x/abs/
4. Intramolecular Cross-linking: Kim and Greenburg; http://www.blackwell-synergy.com/links/doi/10.1111/j.1525-1594.2004.07345.x/abs/
5. Polymerization: Advantek Biologics Limited http://www.fmshk.com.hk/hkabth/ss/Haemoglobin-Based%20Oxygen%20Carriers%20for%20Anaemia(200311).pdf
6. Conjugation: Kim and Greenburg; http://www.blackwell-synergy.com/links/doi/10.1111/j.1525-1594.2004.07345.x/abs/
7. Encapsulation: Kim and Greenburg; http://www.blackwell-synergy.com/links/doi/10.1111/j.1525-1594.2004.07345.x/abs/
8. Graph of leading HBOCs: Advantek Biologics Limited; http://www.fmshk.com.hk/hkabth/ss/Haemoglobin-Based%20Oxygen%20Carriers%20for%20Anaemia(200311).pdf
9. Hemopure Clinical Trials Graph: Advantek Biologics Limited; http://www.fmshk.com.hk/hkabth/ss/Haemoglobin-Based%20Oxygen%20Carriers%20for%20Anaemia(200311).pdf

Platelets
1. Activated platelets 1: http://www.healthsystem.virginia.edu/internet/bims_mmsb/home.cfm
2. Activated platelets 2: http://www.trombosedienst-leiden.nl/ html/stolling.htm
3: Activated platelets 3: http://www.med.monash.edu.au/ medicine/box_hill/research/

Website References (top)

Contents

1. History
2. Opinions
3. PFCs
4. HBOCs
5. Platelets

History

Chang TM. Hemoglobin-based red blood cell substitutes.
Artif Organs. 2004 Sep;28(9):789-94.

Kim HW, Greenburg AG. Artificial oxygen carriers as red blood cell substitutes: a selected review and current status.
Artif Organs. 2004 Sep;28(9):813-28.

Kjellstrom BT. Blood substitutes: where do we stand today?
J Intern Med. 2003 May;253(5):495-7.

Rudnicke C. Transfusion alternatives.
J Infus Nurs. 2003 Jan-Feb;26(1):29-33.

Winslow RM. Current status of blood substitute research: towards a new paradigm.
J Intern Med. 2003 May;253(5):508-17.

Opinions

Kim HW, Greenburg AG. Artificial oxygen carriers as red blood cell substitutes: a selected review and current status.
Artif Organs. 2004 Sep;28(9):813-28.

Reid, Thomas J. Hb-based oxygen carriers: are we there yet?
Transfusion. 2003 Feb; 43(2): 280

PFCs

Alliance Pharmaceutical Corp. Oxygent™ Fact Sheet . 28 March 2005 <http://www.allp.com/Oxygent/ox_fact.htm>.

BioSpace. “Alliance Pharmaceutical Corp.” 20 March 1998 . 27 April 2005 . <http://www.biospace.com/company_profile.cfm?CompanyID=1273>. 4/27/05

BioSpace. “Alliance Pharmaceutical Corp. and Beijing Double-Crane Pharmaceutical Co. Ltd. Announce a Memorandum of Understanding Concerning the Development, Licennsins nd Markerting of Oxygent ™ in the People's Republic of China .” PRNewswire-FirstCall. 5 April 2005 . 27 April 2005 . < http://www.biospace.com/news_story.cfm?StoryID=19613620&full=1>.

BioSpace. “Alliance Pharmaceutical Corp. and LEO Pharma Modify Exclusivity Agreement Related to the Development and Marketing of Oxygent™ in Europe and Canada .” PRNewswire-FirstCall. 2 March 2005 . 27 April 2005 . <http://www.biospace.com/news_story.cfm?StoryID=19242620&full=1>.

BioSpace. “Alliance Pharmaceutical Corp. Announces Change in Senior Executive Status and Provides Updated on Revised Oxygent™ Development Plan Following Feedback From European Regulatory Authorities.” PRNewswire-FirstCall . 6 Oct. 2004 . 27 April 2005 . <http://www.biospace.com/news_story.cfm?StoryID=17583420&full=1>.

Business Wire. “Sanguine Provides a Shareholder Update on the Progress of PHER-O2 Testing.” 25 April 2005 . 26 April 2005 . <http://biz.yahoo.com/bw/050425/255030.html?.v=1>.

Cohn, Stephen M. MD, FACS. “ Oxygen Therapeutics in Trauma and Surgery.” Journal of Trauma-Injury Infection & Critical Care 54.5 (2003). 28 March 2005 <http://gateway.ut.ovid.com.revproxy.brown.edu/gw1/ovidweb.cgi >

FDA Official. “re: blood substitutes.” E-mail to Evan Werlin. 15 April 2005 .

Fridey, Joy, MD, "Oxygen carriers as alternatives to red cell transfusion," UpToDate, 2005.

Keipert, Peter E., Ph. D. “A Temporary Intravenous Oxygen Carrier: Physical Properties and Developmental Status.” 28 March 2005 <http://www.allp.com/Oxygent/OX_PETER.HTM>

Kiral, Richard M., Ph. D., and David P. Evitts. “Development and Properties of Oxycyte: A New Perfluorocarbon Blood Substitute.” 13 Nov. 2002 . 28 March 2005 . <http://www.sybd.com/pages/sybdreport5.html>

Kirschman, Ruth Ann BS, RN, C, WHNP. “Finding Alternatives to Blood Transfusion.” Nursing 34.6 (2004). 28 March 2005 <http://www.nursing2004.com/pt/re/nursing/fulltext.00152193-200406000-00046.htm;jsessionid=Cu9wOqabKxAHRs9DNVuVcYG919ZyxCGy6OnDUph9JiSiNJ8alOaQ!-264389797!-949856032!9001!-1>.

Kovelenov, A.Yu., B.O.Voitenkov, E.I.Mayevsky, and S.Yu. Pushkin. “ Perspectives of Using Perfluorocarbon Compound in HIV-Infection (Abstract).” 3 rd Baltic Region Conference “Together Against AIDS!”. Final Program (2003). 19 April 2005 . <http://www.perftoran.ru/Eng/modules.php?name=News&file=article&sid=29>.

Lexico Publishing Group, LLC. “Surfactant.” 28 April 2005 . <http://dictionary.reference.com/search?q=surfactant>.

Loubser, Paul G., MD. “Applied Medical Research & Development ANH Bulletin.” Dec. 1998. 28 April 2005 . <http://www.hematicus.com/Bull10.html>.

Maevsky, E.I. “Clinical Results of Perftoran Application: Present and Future (Abstract).” Artificial Blood 11.1 (2003). 19 April 2005 . <http://www.perftoran.ru/Eng/modules.php?name=News&file=article&sid=20>.

Nicora, Robert, Richard Kiral, and Douglas Kornbrust. “Nonclinical Safety of Oxycyte-An Intravenous Perfluorocarbon Oxygen Carrier.” 13 Nov. 2002 . 20 April 2005 . <htttp://www.sybd.com/pages/sybdreport8.html>.

Riess, Jean G. “Understanding the Fundamentals of Perfluorocarbons and Perfluorocarbon Emulsions Relevant to In Vivo Oxygen Delivery.” Artificial Cells, Blood Substitutes, and Biotechnology: An International Journal 33.1 (2005): 47-63.

Robinson, Alicia. “Fake Blood Passes Early Tests.” Los Angeles Times: Costa Mesa Daily Pilot 13 Nov. 2003 . 28 March 2005 < http://www.sybd.com/pages/sybdreport9.html>

Sanguine Corp. Sanguine Products 28 March 2005 <http://www.sanguine-corp.com/products.htm>.

Sarteschi, Lelio Mario. “Re: Blood Substitutes.” E-mail to Evan Werlin. 25 April 2005 .

Synthetic Blood International. “Patients Enrolled in Synthetic Blood International's Phase II Oxycyte Trial .” 18 April 2005 . 26 April 2005 . < http://www.sybd.com/pages/sybdnews2005.html#Anchor-Synthetic-041805.>

Zhiburt, Eugene B., and Anna V. Kovalenko. “Perftoran is Reliable Alternative of Blood Transfusion.” Blood Banking and Transfusion Medicine 1.2 (2003). 19 April 2005 . <http://www.perftoran.ru/Eng/modules.php?name=News&file=article&sid=18>.

HBOCs

Beauchesne, Pascal (2004) The Design of Blood Substitutes: Oxygen Carriers. BioTeachJournal.

Creteur, Sibbald (2000) Hemoglobin Solutions – Not just red blood cell substitutes. Crit Care Med.

Fridey, Joy (2004) Oxygen Carriers as Alternatives to Red Cell Transfusion. UpToDate.

Kim, Hae Won & Greenburg, A. Gerson (2004) Artificial Oxygen Carriers as Red Blood Cell Substitutes: A Selected Review and Current Status. Artificial Organs .

Kim, Hae Won & Greenburg, A. Gerson (2004) Hemoglobin-Based Oxygen Carriers. Critical Care .

Reid, Thomas J. (2003) Hb-Based Oxygen Carriers: Are we there yet? Transfusion.

Platelets

Alving BM, Reid TJ, Fratantoni JC, Finlayson JS. Frozen platelets and platelet substitutes in transfusion medicine.
Transfusion. 1997 Aug;37(8):866-76.

Blajchman MA. Substitutes and alternatives to platelet transfusions in thrombocytopenic patients.
J Thromb Haemost. 2003 Jul;1(7):1637-41.

Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.
Blood. 1995 Jan 15;85(2):402-13.

Corash L. New technologies for the inactivation of infectious pathogens in cellular blood components and the development of platelet substitutes.
Baillieres Best Pract Res Clin Haematol. 2000 Dec;13(4):549-63.

Goodnough LT, Shander A, Brecher ME. Transfusion medicine: looking to the future.
Lancet. 2003 Jan 11;361(9352):161-9.

Lee DH, Blajchman MA. Novel treatment modalities: new platelet preparations and substitutes.
Br J Haematol. 2001 Sep;114(3):496-505.

Silberman S. Platelets: preparations, transfusion, modifications, and substitutes.
Arch Pathol Lab Med. 1999 Oct;123(10):889-94.

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