Pakzaban, et al
Since it was shown that the pretreatment of islet cells to monoclonal antibody to MHC-1 antigen blocked cytotoxic T lymphocyte production and that pretreatment with F(ab)2 fragments to liver and islet cells prevents graft rejection, This research group attempted to apply this method of immune system circumvention to the CNS (983).
Pakzaban, et al first confirmed presence of MHC-1 antigens on porcine neurons. They hen looked at the striatal xenografts and assessed survival with markers (immunostaining) and immunoreactivity to those markers. They found no significant difference in survival between F(ab)2 and CsA recipients. However, there was a significant difference in graft volumes, and are unclear as to whether this is a partial suppression. They inferred that this method leads the host to donor-induced tolerance (993), and that this method could be a new novel treatment when conventional immunosuppression does not suffice (994).