THE COBRE CENTER FOR CANCER SIGNALING NETWORKS IS NOW ACCEPTING APPLICATIONS FOR PILOT PROJECTS. THE DUE DATE IS May 15, 2013. PLEASE SEE THE RFA FOR DETAILS.

The Center for Cancer Signaling Networks (CCSN) in the Division of Biology and Medicine is supported by a type III Transitional COBRE grant. The major goal of this grant mechanism is to provide support for two core facilities in the division with the ultimate goal of making these cores self-sustaining. The grant supports an administrative core, a genomics core, and a mouse transgenic and gene targeting core. The grant also supports a limited number of pilot projects that focus on stimulating use of one or both of the cores. The pilot projects are administered through the administrative core.

Facilities

Administrative Core

Director

Walter Atwood, Ph.D.
Professor of Medical Science
Department of Molecular Biology, Cell Biology and Biochemistry
Walter_Atwood@brown.edu
(401)863-3116

Administrative Manager

Patricia Werner
COBRE Program Manager
Department of Molecular Biology, Cell Biology and Biochemistry
Patricia_Werner@brown.edu
(401)863-2048

Program Coordinator

Pamela Swiatek
Director of Research Operations & Major Proposal Coordinator
Department of BioMed Medical Affairs Pamela_Swiatek@brown.edu
(401)863-3228

The administrative core functions to support the scientific goals of the center by providing administrative structure for the coordination of activities of the Principal Investigator, the Program Coordinator, and the Core Directors. These functions include: administrative support for the PI, administrative support for the cores, collection of financial records from core directors, maintaining financial records of the center, preparing an annual financial report for the University and the NCRR, coordinating the activities of the IAC and EAC. Other activities include community outreach, web site maintenance, and administration of the pilot project mechanism.

Genomics Core

Facility Director

John Sedivy, Ph.D.
Professor of Medical Science
Department of Molecular Biology, Cell Biology and Biochemistry
John_Sedivy@brown.edu
(401) 863-7631

Scientific Manager

Christoph Schorl, Dipl.-Biol., MSc, PhD
Assistant Professor of Biology (Research)
Department of Molecular Biology, Cell Biology and Biochemistry
Christoph_Schorl@brown.edu
(401) 863-2875

The Genomics Core provides modern state-of-the-art genomics services to a wide customer base at Brown University and in the community. Several types of gene arrays are offered based on the Affymetrix platform. These include standard gene chip arrays, exon arrays, Gene ST arrays, and microRNA arrays. Illumina GAIIx and HiSeq single molecule sequencers provide in-house deep sequencing services. The facility also houses two state-of-the-art BioAnalyzers and many smaller pieces of equipment.

The Genomics Core Facility has been supported by grants from the National Center for Research Resources (P30 RR031153) and the National Insitute fo General Medical Sciences (8P30 GM103410) from the National Institutes of Health.

Go to the Genomics Core Facility

Mouse Transgenic and Gene Targeting Facility

Facility Director

Richard Freiman, Ph.D.
Associate Professor of Medical Science
Department of Molecular Biology, Cell Biology and Biochemistry
Richard_Freiman@brown.edu
(401) 863-9633

Laboratory Manager

Kirsten Sigrist
(401) 863-9544
Kirsten_Sigrist@brown.edu

The function of the Transgenic Mouse and Gene Targeting Core is to support investigators both through generation of transgenic and mutant mice. Our mission is to facilitate access to mouse models of human diseases. The transgenic core provides targeted mutagenesis of embryonic stem cells, generation of ES cell chimeras, pronuclear injection, re-derivation of mice by embryo transfer, and cryogenic preservation and storage of embryos. The facility provides expert support to guide investigators through all steps in a targeted mutagenesis project.

The Mouse Transgenic and Gene Targeting Core Facility has been supported by grants from the National Center for Research Resources (P30 RR031153) and the National Insitute fo General Medical Sciences (8P30 GM103410) from the National Institutes of Health.

Go to the Mouse Transgenic and Gene Targeting Facility